吴成君

个人信息Personal Information

教授

博士生导师

硕士生导师

性别:男

毕业院校:清华大学北京协和医学院

学位:博士

所在单位:生物医学工程学院

办公地点:创新园大厦A1215

联系方式:wcj5532@dlut.edu.cn

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吴成君, 博士毕业于清大学医学部&北京和医学院20106月至20152月在瑞典拉大学生物医学中心分从事博士后和科研教学工作。20153月开始受聘于隆德大学生物医学中心,研究,从事科研教学,并于20173身教20193月作海外引人才入理工大学生物医学工程学院,教授称,博

 

吴成君教授主要从事与头颈癌和女性宫颈生相关的人乳瘤病毒(HPV, Human Papilloma Virus胞与分子生物研究。主要从表观遗传学的角度研究HPV16诱发细胞癌的分子机制以及抗瘤小分子物的筛选

 

近五年做课题负责人主持瑞典国家级项目和省级项目三面上助两。在国知名Nucleic Acids ResInternational Journal of CancerInt J Mol Sci., J Virol等以第一作者或通作者表文章十余篇。近几年表部分文章如下:


1. Cui H, Ma R, Hu T, Xiao GG, Wu C#. Bioinformatics Analysis Highlights Five Differentially Expressed Genes as Prognostic Biomarkers of Cervical Cancer and Novel Option for Anticancer Treatment. Front Cell Infect Microbiol. 2022 (JCR 一区, IF: 6.07)

2. Zheng Y, Li X, Jiao Y, Wu C#.  High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation. Front Cell Infect Microbiol. 2022 (JCR 一区, IF: 6.07)

3. Fang L, Liu Q, Cui H, Zheng Y, Wu C#. Bioinformatics Analysis Highlight Differentially Expressed CCNB1 and PLK1 Genes as Potential Anti-Breast Cancer Drug Targets and Prognostic Markers. Genes (Basel). 2022 (JCR 二区, IF: 4.14)

4.  Liu Q, Fang L, Wu C#. Alternative Splicing and Isoforms: From Mechanisms to Diseases. Genes (Basel).2022  (JCR 二区, IF: 4.14)

5. Yunji Zheng, Johanna Jönsson, Shirin Shoj Chaghervand, Naoko Kajitani, Chengjun Wu #, Stefan Schwartz#.  hnRNP A1 and hnRNP A2 inhibit splicing to HPV16 splice site SA409 through a UAG-containing sequence in the E7 coding region. Journal Of Virology   2020 (JCR 一区, IF: 6.54)

6. Zheng, YJ; Cui XX; Nilsson, K; Yu, HR; Wu, CJ *; StefanSchwartza,* Efficient production of HPV16 E2 proteinfrom HPV16 late mRNA sspliced from SD880 to SA2709. Virus Research   2020 (JCR 二区, IF: 6.28)

Wu, CJ; Nilsson, K; Zheng, YJ; Ekenstierna, C; Sugiyama, N; Forslund, O; Kajitani, N; Yu, HR; Wennerberg, J; Ekblad, L; Schwartz, S Short half-life of HPV16 E6 and E7 mRNAs sensitizes HPV16-positive tonsillar cancer cell line HN26 to DNA-damaging drugs:  International Journal of Cancer  2019 (JCR 一区, IF: 7.36)

8. Nilsson, K#; Wu, CJ#*; Kajitani, N; Yu, HR; Tsimtsirakis, E; Gong, LJ; Winquist, EB; Glahder, J; Ekblad, L; Wennerberg, J; Schwartz, S.The DNA damage response activates HPV16 late gene expression at the level of RNA processing Nucleic  Acids Research.  2018 (JCR 一区, IF: 19.16) 

9. Yu, HR; Wu, CJ*; Nilsson, K; Schwartz, S. Adenosine causes read through into the late region of the HPV16 genome in a guanosine dependent manner Virology, 2018 (JCR 三区, IF: 3.36) 

10. Wu, CJ; Kajitani, N; Schwartz, S. Splicing and Polyadenylation of Human Papillomavirus Type 16 mRNAs International Journal of Molecular Science, 2018 (JCR 一区, IF:6.20) 



  • 教育经历Education Background
  • 工作经历Work Experience
    2019.3 至今
    • 大连理工大学电信学部
  • 研究方向Research Focus
  • 社会兼职Social Affiliations