吴成君

基本信息Personal Information

教授

硕士生导师

主要任职:无

性别:男

出生日期:1977-08-06

毕业院校:清华大学北京协和医学院

学位:博士

在职信息:在职

所在单位:生物医学工程学院

办公地点:创新园大厦A1215

联系方式:wcj5532@dlut.edu.cn

电子邮箱:

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个人简介Personal Profile

       吴成君2009年博士毕业于清华大学医学部&北京协和医学院,获得病原生物学博士学位。20106月至20152月在瑞典乌普萨拉大学生物医学中心分别从事博士后和科研教学工作。20153月开始受聘于隆德大学生物医学中心,研究员,从事科研教学,并于20173月获得终身教职。2019年三月左外海外引进人才入职大连理工大学生物医学工程学院,教授职称,博导。

吴成君教授主要从事与头颈癌和女性宫颈癌发生相关的人乳头瘤病毒(HPV, Human Papilloma Virus)的细胞与分子生物研究。主要从表观遗传学的角度研究HPV16诱发细胞癌变的分子机制以及抗肿瘤小分子药物的筛选。此外吴成君教授还从事与社区肺炎高度相关的人腺病毒(Human Adenovirus)的诊断试剂的开发与应用。

近几年做为子课题负责人主持瑞典国家级项目和省级项目三项。在国际知名杂志Nucleic Acids ResInternational Journal of CancerInt J Mol Sci. Virology等以第一作者或通讯作者发表文章十余篇。近几年发表部分文章如下:

1. Chengjun Wu, Kersti Nilsson, Yunji Zheng, Camilla Ekenstierna, Natsuki Sugiyama, OlaForslund, Naoko Kajitani, Haoran Yu, Johan Wennerberg, Lars Ekblad, Stefan Schwarts. Short half-life of HPV16 E6 and E7 mRNAs sensitizes HPV16-positive tonsillar cancer cellsto DNA-damaging drugs. International Journal of Cancer  20191444):297-310  IF: 7.36

2. Ola Forslund, Natsuki Sugiyama, Chengjun Wu, Naveen Ravi, Yuesheng Jin, Sabine Swoboda, Fredrik Andersson, Davit Bzhalava, Emilie Hultin, Kajsa Paulsson, Joakim Dillner, Stefan Schwartz, Johan Wennerberg, Lars Ekblad    A novel human in vitro papillomavirus type 16 positive tonsil cancer cell line with high sensitivity to radiation and cisplatin BMC Cancer 2019 Mar 25;19(1):265. IF: 3.28

3. Kersti Nilsson#, Chengjun Wu# 1,  Kajitani N., Glahder, J., Haoran Yu, Schwartz1, S.The DNA damage response can induce HPV16 late gene expression by inhibiting theHPV16 early polyadenylation signal and Activating HPV16 late splice sites  Nuclear Acid Research 2018 Jun 1;46(10):5029-5049 (并列一作和通讯作者) IF: 11.56

4. Haoran Yu, Chengjun Wu*, Kersti Nilsson, Naoko Kajitani, Stefan Schwartz*Adenosine causes read-through into the late region of the HPV16 genome in a guanosine dependent manner Virology  2018 Jun 1;521:1-19. (共同通讯作者) IF: 3.37

5. Chengjun Wu, Kajitani N., Stefan Schwart Splicing and polyadenylation of human papillomavirus type 16 mRNAS. International Journal of Molecular Sciences 2017 Feb 9;18(2)  IF: 3.68

6. Chengjun Wu, Xiaofang Cao, Di Yu, Elisabeth J. M. Huijbers, Magnus Essand, Göran Akusjärvi, Staffan Johansson, Cathrina Svensson HAdV-2 suppressed growth of SV40 T antigen transformed mouse mammary epithelial cell-induced tumours in SCID mice.

Virology. 2015 18;489:44   IF: 3.37

7.Chengjun Wu, Lufeng Bai, Zhiqun Li, Charles E. Samuel, Göran Akusjärvi and Catharina Svensson Poor growth of human adenovirus-12 compared to adenovirus-2 correlates with a failure to impair PKR activation during the late phase of infection. Virology 2015 15;475:120-128.  IF: 3.37

8. Li Guo*, Chengjun Wu*, Hongli Zhou, Chao Wu, Glaucia Paranhos-Bacala, Guy Vemet,

Qi Jin, Jianwei Wang, Tao Hung  Identification of  DNA-binding protein (DBP), a nonstructural protein, as an immunogen with diagnostic potential in human. Co-first author Plos One 2013 8:e56708  IF: 3.53

9. Chengjun Wu, Daniel Öberg, Asif Rashid, Rajesh Gupta, StaffanJohansson, Göran

Akusjärvi and Catharina Svensson  A mouse mammary epithelial cell line permissive for highly efficient human adenovirus growth. Virology 2013 20:363-371  IF: 3.37

10. Chenjun Wu, Xiaobo Lei, Jianwei Wang, Tao Hung  Generation of a replication deficient recombinant human adenovirus type 35 vector using bacterial-mediated  homologous recombination J. Virol. Methods 2012177: 55-63.  IF: 1.91


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