Highly active bifunctional salenTi(IV) catalysts for asymmetric cyanosilylation of aldehydes and TMSCN
发表时间：2019-03-09
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- 论文类型：
- 期刊论文
- 第一作者：
- Wen, Ye Qian
- 通讯作者：
- Lu, XB (reprint author), Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China.
- 合写作者：
- Ren, Wei Min,Lu, Xiao Bing
- 发表时间：
- 2011-11-01
- 发表刊物：
- CHINESE CHEMICAL LETTERS
- 收录刊物：
- Scopus、SCIE、ISTIC、CSCD
- 文献类型：
- J
- 卷号：
- 22
- 期号：
- 11
- 页面范围：
- 1285-1288
- ISSN号：
- 1001-8417
- 关键字：
- Cyanohydrin; Bifunctional catalyst; Salen; TMSCN; Diphenylphosphine oxide
- 摘要：
- A novel enantiopure salen ligand bearing a diphenylphosphine oxide on the 3-position of one aromatic ring was synthesized and combined with Ti(Oi-Pr)(4) as a monometallic bifunctional catalyst for asymmetric cyanosilylation reaction of aldehydes with trimethylsilyl cyanide (TMSCN). The catalyst system exhibited excellent activity and moderate enantioselectivity. The addition of TMSCN to 4-nitrobenzaldehyde in the presence of 1 mol% catalyst loading could complete within 10 min at ambient temperature. An intramolecularly cooperative catalysis was observed in this system wherein the central metal Ti(IV) is suggested to play a role of Lewis acid to activate aldehydes while the appended diphenylphosphine oxide worked as Lewis base to activate TMSCN. (C) 2011 Xiao Bing Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
- 是否译文：
- 否
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