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新型阳离子脂质体制备及应用研究
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Indexed by:期刊论文

Date of Publication:2019-02-15

Journal:化学研究与应用

Included Journals:PKU

Volume:31

Issue:2

Page Number:177-183

ISSN No.:1004-1656

Key Words:阳离子脂质体;基因;药物;诊断试剂;研究进展

Abstract:阳离子脂质体是目前使用最广泛的脂质体之一, 作为载药系统, 已被广泛应用于临床诊断和治疗.作为纳米型载体, 它既可以包载基因/药物, 也可以包载诊断试剂, 还可以两者同时包载.将阳离子脂质体应用于医药, 既可以提高药物的体内稳定性, 有利于药物在体内的长循环;又可以缓释药物, 延缓肾代谢, 降低药物的毒副作用.本文检索了近年来国内外关于阳离子脂质体制备研究的相关文献, 分析和归纳了包括固醇衍生物阳离子脂质体、氨基酸/多肽阳离子脂质体以及含糖阳离子脂质体等多种类型的新型阳离子脂质体的制备和应用研究, 以便为将来的深入研究提供参考和借鉴.

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Gender:Male

Alma Mater:Dalian University of Technology

Degree:Doctoral Degree

School/Department:State Key Laboratroy of Fine Chemicals

Discipline:Applied Chemistry. Fine Chemicals. Biochemical Engineering

Business Address:West Campus E-204

Contact Information:xiaoyi@dlut.edu.cn 0411-84986251

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