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    谢晴

    • 高级工程师    
    • 主要任职:无
    • 性别:女
    • 毕业院校:大连理工大学
    • 学位:博士
    • 在职信息:在职
    • 所在单位:环境学院
    • 学科:环境工程
    • 办公地点:环境楼A315
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    Unveiling the important roles of coexisting contaminants on photochemical transformations of pharmaceuticals: Fibrate drugs as a case study

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    论文类型:期刊论文

    第一作者:Zhang, Ya-nan

    通讯作者:Qu, J (reprint author), Northeast Normal Univ, Sch Environm, Changchun 130117, Jilin, Peoples R China.

    合写作者:Zhou, Yangjian,Qu, Jiao,Chen, Jingwen,Zhao, Jianchen,Lu, Ying,Li, Chao,Xie, Qing,Peijnenburg, Willie J. G. M.

    发表时间:2018-09-15

    发表刊物:JOURNAL OF HAZARDOUS MATERIALS

    收录刊物:PubMed、SCIE

    卷号:358

    页面范围:216-221

    ISSN号:0304-3894

    关键字:Photodegradation; Coexisting contaminants; Fibrate drugs; Photochemically produced reactive intermediates; Excited states

    摘要:Pharmaceuticals are a group of ubiquitous emerging pollutants, many of which have been shown to undergo efficient photolysis in the environment. Photochemically produced reactive intermediates (PPRIs) sensitized by the pharmaceuticals in sunlit natural waters may induce photodegradation of coexisting compounds. In this study, the roles of coexisting contaminants on the phototransformation of pharmaceuticals were unveiled with the fibrate drugs gemfibrozil (GMF), fenofibrate (ENE), and fenofibric acid (FNFA) as model compounds. GMF undergoes initial concentration dependent photodegradation due to the involvement of singlet oxygen (102) initiated self-sensitized photolysis, and undergoes pH dependent photodegradation due to dissociation and hydroxyl radical (center dot OH) generation. The decarboxylated intermediates of GMF and coexisting FNFA significantly accelerated the photodegradation of GMF. The promotional effects of the decarboxylated intermediates are attributed to generation of PPRIs, e.g. O-1(2), superoxide (O-2 center dot(-)), that subsequently react with GMF. Besides, FNFA can also promote the photodegradation of GMF through the electron transfer reaction from ground state GMF to excited state FNFA, leading to the formation of decarboxylated intermediates. The formed intermediates can subsequently also facilitate GMF photodegradation. The results presented here provided valuable novel insights into the effects of coexisting contaminants on the photodegradation of pharmaceuticals in polluted waters.