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    谢晴

    • 高级工程师    
    • 主要任职:无
    • 性别:女
    • 毕业院校:大连理工大学
    • 学位:博士
    • 在职信息:在职
    • 所在单位:环境学院
    • 学科:环境工程
    • 办公地点:环境楼A315
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    Photolysis of three antiviral drugs acyclovir, zidovudine and lamivudine in surface freshwater and seawater

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    论文类型:期刊论文

    第一作者:Zhou, Chengzhi

    通讯作者:Chen, JW (reprint author), Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn MOE, Linggong Rd 2, Dalian 116024, Peoples R China.

    合写作者:Chen, Jingwen,Xie, Qing,Wei, Xiaoxuan,Zhang, Ya-nan,Fu, Zhiqiang

    发表时间:2015-11-01

    发表刊物:CHEMOSPHERE

    收录刊物:Scopus、PubMed、EI、SCIE

    卷号:138

    页面范围:792-797

    ISSN号:0045-6535

    关键字:Antiviral drug; Photolysis; Aquatic environment; Photosensitizer

    摘要:Photodegradation is an important elimination process for many pharmaceuticals in surface waters. In this study, photodegradation of three antiviral drugs, acyclovir, zidovudine, and lamivudine, was investigated in pure water, freshwater, and seawater under the irradiation of simulated sunlight. Results showed that zidovudine was easily transformed via direct photolysis, while acyclovir and lamivudine were mainly transformed via indirect photolysis. We found that in freshwater, nitrate enhanced the photodegradation of the three antiviral drugs, bicarbonate promoted the photodegradation of acyclovir, and dissolved organic matter (DOM) accelerated the photolysis of acyclovir and lamivudine. In seawater, the photolysis of acyclovir was not susceptible to Cl-, Br- and ionic strength; however, the photolysis of zidovudine was inhibited by Cl- and Br-, and the photolysis of lamivudine was enhanced by Cl-, Br- and ionic strength. Second-order reaction rate constants for the three antiviral drugs with O-1(2) (k(102)) and (OH)-O-center dot (k(OH)) were also measured. These results are important for fate and ecological risk assessment of the antiviral drugs in natural waters. (C) 2015 Elsevier Ltd. All rights reserved.