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    谢晴

    • 高级工程师    
    • 主要任职:无
    • 性别:女
    • 毕业院校:大连理工大学
    • 学位:博士
    • 在职信息:在职
    • 所在单位:环境学院
    • 学科:环境工程
    • 办公地点:环境楼A315
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    Photochemical behavior of antibiotics impacted by complexation effects of concomitant metals: a case for ciprofloxacin and Cu(II)

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    论文类型:期刊论文

    第一作者:Wei, Xiaoxuan

    通讯作者:Chen, JW (reprint author), Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn MOE, Dalian 116024, Peoples R China.

    合写作者:Chen, Jingwen,Xie, Qing,Zhang, Siyu,Li, Yingjie,Zhang, Yifei,Xie, Hongbin

    发表时间:2015-07-01

    发表刊物:ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS

    收录刊物:Scopus、PubMed、SCIE

    卷号:17

    期号:7

    页面范围:1220-1227

    ISSN号:2050-7887

    摘要:Many water bodies, especially those adjacent to aquaculture and livestock breeding areas, are contaminated by both antibiotics and transition metals. However, the effects of the interaction between antibiotics and transition metals on the environmental behavior and the ecotoxicology of antibiotics are largely unknown. We hypothesized that antibiotics may coordinately bind with metal ions, and this complexation may affect the environmental photochemical behavior of antibiotics. We took ciprofloxacin (CIP) and Cu(II) as a case, and employed simulated sunlight experiments and density functional theory calculations to investigate the underlying reaction mechanisms. The results showed that monovalent cationic ciprofloxacin (H2CIP+) that is predominant in the normal pH range (6-9) of surface waters can chelate with hydrated Cu(II) to form [Cu(H2CIP)(H2O)(4)](3+). Compared with H2CIP+, [Cu(H2CIP)(H2O)(4)](3+) has different molecular orbitals, and atomic charge distribution. As a result, [Cu(H2CIP)(H2O)(4)](3+) showed dissimilar light absorption properties, slower direct photolytic rates, lower O-1(2) generation ability and weaker reactivity towards O-1(2). Due to the Cu(II) complexation, the apparent photodegradation of H2CIP+ was inhibited, and the photolytic pathways and product distribution were altered. This study implies that for an accurate ecological risk assessment of antibiotics under transition metal co-contamination conditions, the effects of metal complexation should be considered.