李阳
Personal Homepage
Paper Publications
Enantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides
Hits:

Indexed by:期刊论文

First Author:Du, Wei

Correspondence Author:Yang, D (reprint author), Univ Hong Kong, Dept Chem, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.

Co-author:Gu, Qiangshuai,Li, Yang,Lin, Zhenyang,Yang, Dan

Date of Publication:2017-01-20

Journal:ORGANIC LETTERS

Included Journals:SCIE

Volume:19

Issue:2

Page Number:316-319

ISSN No.:1523-7060

Abstract:The catalyst system of Pd(TFA)(2)/(S,S)-diPh-pyrox is reported to promote the highly efficient enantioselective oxidative cascade cyclization of alkene-tethered aliphatic acrylamides under mild aerobic conditions. A series of pyrrolizidine derivatives have been synthesized in good yield and excellent enantioselectivity. Deuterium-labeling experiments have revealed that the reaction proceeded through an anti-aminopalladation (anti-AP) pathway with high selectivity. The transition states for the anti-AP step have been calculated to account for the observed enantioselectivity.

Personal information

Associate Professor
Supervisor of Master's Candidates

Gender:Female

Alma Mater:辽宁师范大学

Degree:Doctoral Degree

School/Department:化工海洋与生命学院

Discipline:Applied Chemistry. Chemical Engineering. Fine Chemicals

Contact Information:chyangli@dlut.edu.cn

Click:

Open time:..

The Last Update Time:..


Address: No.2 Linggong Road, Ganjingzi District, Dalian City, Liaoning Province, P.R.C., 116024

MOBILE Version