There is not only the same significance, but also a great similarity between the deepening study of the micro- and macro-cosmos. When we go to the seas of stars, we must not ignore the principals guiding the molecules, electrons and photons. These micro basics constitute the fundamental building blocks of ensemble characteristics. To address the issues of micro-scale observing, it is a necessity and challenge to design the fluorophore scaffold and the optical microscope to enable the analysis of molecular events, including interactions and distributions. This multidisciplinary research works on the fields of chemistry, optics, computer science and mathematics. It is hoping to super-resolving the fluorescence information to push the boundaries of living cellular studies and diagnostic approaches.

Dr. Ye Zhiwei obtained his bachelor degree at Dalian University of Technology from 2007-2011. Then, he obtained admission qualification and followed Prof. Xiao Yi to pursue a doctoral degree. After several years of hard training on the multidisciplinary fields, he obtained doctoral degree at applied chemistry on 2020. He is now an associate professor at Dalian University of Technology. His research interest covers the fluorescent dyes for super-resolution imaging. He has published several important papers on JACS, Angew. Chem., Int. Ed., Anal. Chem. etc., and served as a reviewer for Nature Communications.

We are a team composing of multidisciplinary background. We warmly welcome applicants from worldwide with interests in fluorescent probes, microscopy and image processing. We have two positions for Post doctoral candidates, one/two positions for PhD candidates, two/three positions for master candidates every year. Please feel free to contact us.

It would be helpful if you could provide us with your cvs and publications. More details on the group site：https://yezhiwei90.github.io/

1. Projects

1.Engineering of fluorescent dyes for super-resolution imaging. China Postdoctoral Science Foundation, 2020.06-2022.06, project director, 630k yuan.

2.Development of rhodamine fluorophores for super-resolution imaging. National Natural Science Foundation of China, 2021.01-2023.12, project director, 240k yuan.

3.Fluorescent fluorophores for multi-color single-molecule localization superresolution imaging. China Postdoctoral Science Foundation, project director, 80k yuan.

2. Publications

1. Ye Zhiwei,# Yang Wei,#* Wang Chao,# Zheng Ying,# Chi Weijie, Liu Xiaogang,* Huang Zhenlong, Li Xiaoyuan, Xiao Yi.* Quaternary Piperazine-Substituted Rhodamines with Enhanced Brightness for Super-Resolution Imaging. Journal of the American Chemical Society, 2019,141(37):14491–14495. IF: 15(15.1), JCR: Q1(CHEMISTRY, MULTIDISCIPLINARY)

2. Ye Zhiwei,# Yu Haibo,#* Yang Wei,# Zheng Ying,# Li Ning, Bian Hui, Wang Zechen, Liu Qiang, Song Youtao, Zhang Mingyan, Xiao Yi.* Strategy to Lengthen the On-Time of Photochromic Rhodamine Spirolactam for Super-Resolution Photoactivated Localization Microscopy. Journal of the American Chemical Society, 2019,141(16):6527–6536. IF: 15(15.1), JCR: Q1(CHEMISTRY, MULTIDISCIPLINARY)

3. Ye Zhiwei,# Yang Wei,#* Zheng Ying, Wang Shujing, Zhang Xiaodong, Yu Haibo, Li Shuangshuang, Luo Chunxiong,* Peng Xiaojun,* Xiao Yi.* Integrating a Far-Red Fluorescent Probe with a Microfluidic Platform for Super-Resolution Imaging of Live Erythrocyte Membrane Dynamics. Angewandte Chemie International Edition, 2022,61(45):e202211540. IF: 16.6(15.3), JCR:Q1(CHEMISTRY, MULTIDISCIPLINARY)

4. Zheng Ying,# Ye Zhiwei,#,*(co-fisrt author，co-correspondence) Zhang Xue, Xiao Yi.* Recruiting Rate Determines the Blinking Propensity of Rhodamine Fluorophores for Super-Resolution Imaging. Journal of the American Chemical Society, 2023,145(9):5125–5133. IF: 15(15.1), JCR: Q1(CHEMISTRY, MULTIDISCIPLINARY)

5. Ye Zhiwei, Zheng Ying, Peng Xiaojun, Xiao Yi.* Surpassing the Background Barrier for Multidimensional Single-Molecule Localization Super-Resolution Imaging: A Case of Lysosome-Exclusively Turn-on Probe. Analytical Chemistry, 2022, 94(22): 7990–7995. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

6. Zheng Ying,# Ye Zhiwei,#*(co-fisrt author) Liu Zengjin, Yang Wei, Zhang Xinfu, Yang Youjun,* Xiao Yi.* Nitroso-Caged Rhodamine: A Superior Green Light-Activatable Fluorophore for Single-Molecule Localization Super-Resolution Imaging. Analytical Chemistry, 2021, 93(22):7833–7842. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

7. Zheng Ying,# Ye Zhiwei,#,*(co-fisrt author，co-correspondence) Xiao Yi.* Subtle Structural Translation Magically Modulates the Super-Resolution Imaging of Self-Blinking Rhodamines, Analytical Chemistry, 2023,95(8):4172–4179. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

8. He Haihong,# Ye Zhiwei,#(co-fisrt author) Xiao Yi,* Yang Wei,* Qian Xuhong,* Yang Youjun.*Super-Resolution Monitoring of Mitochondrial Dynamics upon Time-Gated Photo-Triggered Release of Nitric Oxide. Analytical Chemistry, 2018,90(3):2164–2169. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

9. He Haihong,# Ye Zhiwei,#(co-fisrt author) Zheng Ying, Xu Xiu, Guo Chunlei, Xiao Yi,* Yang Wei,* Qian Xuhong,* Yang Youjun.* Super-Resolution Imaging of Lysosomes with a Nitroso-Caged Rhodamine. Chemical Communications, 2018,54(23): 2842–2845. IF: 4.9(4.9), JCR: Q2(CHEMISTRY, MULTIDISCIPLINARY)

10. Man Huizi,# Bian Hui,# Zhang Xinfu,* Wang Chao, Huang Zhenlong, Yan Yu, Ye Zhiwei,*(co-correspondence) Xiao Yi.* Hybrid labeling system for dSTORM imaging of endoplasmic reticulum for uncovering ultrastructural transformations under stress conditions. Biosensors and Bioelectronics, 2021,189:113378. IF: 12.6(10.8), JCR: Q1(BIOPHYSICS; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; CHEMISTRY, ANALYTICAL; ELECTROCHEMISTRY; NANOSCIENCE & NANOTECHNOLOGY)

11. Man Huizi, Zhou Lin, Zhu Guanghao, Zheng Ying, Ye Zhiwei,*(co-correspondence) Huang Zhenlong, Teng Xinru, Ai Chunzhi, Ge Guangbo,* Xiao Yi*. Super-Resolution Imaging of Autophagy by a Preferred Pair of Self-Labeling Protein Tags and Fluorescent Ligands. Analytical Chemistry, 2022, 94(43): 15057-15066. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

12. Zhang Xiaodong,# Ye Zhiwei, (co-fisrt author)# Zhang Xinfu,* Man Huizi, Huang Zhenlong, Li Ning, Xiao Yi.* A targetable fluorescent probe for dSTORM super-resolution imaging of live cell nucleus DNA. Chemical Communications, 2019,55(13):1951–1954. IF: 4.9(4.9), JCR: Q2(CHEMISTRY, MULTIDISCIPLINARY)