尹磊，药学副教授，美国亚利桑那大学药学博士后，中国药理学会药物代谢专委会青年委员，中国分析药理学委员会青年委员，中国医药生物技术协会药物分析技术分会青年委员，中国药理学会会员，通化市抗击新冠疫情及核酸检测荣誉市民，吉林省优秀青年人才。Journal of Separation Science、 Biomedicine & Pharmacotherapy、Current Analytical Chemistry等SCI杂志审稿人，主要从事小分子药物、蛋白多肽类药物、PEG修饰纳米制剂、高分子聚合物及药用辅料的精准分析及药物代谢动力学研究、非靶向及靶向性代谢组学研究、临床血药浓度监测、食品及环境农药残留分析等。熟悉小分子药物、蛋白多肽类药物、高分子聚合物的一维液相色谱串联质谱方法及二维液相色谱串联质谱方法的开发，迄今共建立了体内药物浓度分析新方法100余项，在Trends in Analytical Chemistry, Anal Chim Acta, Talanta, Journal of Chromatography A, Analyst, Analytical and Bioanalytical Chemistry, Drug Metab Dispos等国际主流杂志发表SCI论文50余篇，申请发明专利5项，近十年来，主持国家自然科学基金青年基金1项，吉林省优秀青年人才基金1项，中央高校基本科研业务费资助引进人才科研专题1项，参与国家自然科学基金重点项目2项，面上项目4项，国家科技重大专项1项。

 作为负责人主持科技项目包括：

（1）国家自然科学基金青年基金项目：基于CID In-Quadrupole 的阿霉素及多尺度PEG化阿霉素比较药代动力学研究（编号：81603182，执行年限：2017/01-2019/12）。

（2）吉林省优秀青年人才基金项目:基于LC-SWATH技术的PEG修饰多柔比星纳米胶束体内多形态成分的精准分析（编号：20190103082JH，执行年限：2019/01-2020/12）。

（3）中央高校基本科研业务费资助引进人才科研专题：基于质谱技术的纳米制剂药代动力学研究（编号：DUT21RC(3)057，执行年限：2021/06-2022/12）。

 以主要参与人参加科技项目包括：

（1）国家自然科学基金重点项目: 药物载体递送系统体内时空命运研究（编号：82030107，执行年限2021-01至2025-12）。

（2）国家自然科学基金重点项目：桥接细胞与整体的纳米药代动力学研究（编号：81430087，执行年限：2015/01-2019/12）。

（3）国家科技重大专项：药物一致性评价关键技术与标准研究（编号：2017ZX09101001，2017/07-2020/07）。

（4）国家自然科学基金面上项目: 基于质谱新技术的PEG-PLA紫杉醇纳米胶束体内多形态成分的精准分析(编号：81872831，执行年限：2019/01-2022/12)。

（5）国家自然科学基金面上项目: 基于连续可变窗口采集技术的泊洛沙姆聚合物LC-HR-MS/MS 分析方法研究与应用(编号：81773692，执行年限：2018/01-2021/12)。

（6）国家自然科学基金面上项目: 新型硒类化合物对晚期前列腺癌的治疗作用及其分子机制的研究 (编号：81272851，执行年限：2014/01-2017/12)。

（7）国家自然科学基金面上项目：几种药物分子的晶型设计构筑及其构动关系（编号：21371024，执行年限：2013/11-2017/12）。

参与横向课题（负责分析方法开发、生物样品测试、数据处理）：

原人参二醇人体药代动力学研究；头孢替坦二钠人体药代动力学研究；落新妇苷大鼠药代动力学研究；苦碟子注射液比格犬药代动力学研究；灯盏花乙素人体药代动力学研究，异丙肌酐片人体药代动力学研究；卡前列腺素甲酯比格犬药代动力学研究；前列腺素E1比格犬药代动力学研究；抗癫痫药临床血药浓度监测液相色谱串联质谱检测试剂盒的研发；甲氨喋呤临床血药浓度监测液相色谱串联质谱检测试剂盒的研发；激素血药浓度监测液相色谱串联质谱检测试剂盒的研发；维生素A、D、E、K血药浓度监测液相色谱串联质谱检测试剂盒的研发。

 

发表论文：

56. Meiyun Shi, Xinyue Zheng, Ning Zhang, Yufeng Guo, Meichen Liu, Lei Yin. Overview of sixteen green analytical chemistry metrics for evaluation of the greenness of analytical methods. TrAC Trends in Analytical Chemistry.2023,166, 117211. 中科院1区TOP, 通讯作者

55.Meiyun Shi, Xinyue Zheng, Hui Jiang, Yuncheng Ge, Ning Zhang, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin. Unraveling the in vivo biological fate of mPEG2000-PDLLA2500-COOH diblock copolymers by LC-MS/MS based on CID in source technique. Anal Chim Acta. 2023, 1267:341375. 通讯作者，JCR Q1 (CHEMISTRY, ANALYTICAL), 中科院1区TOP, 通讯作者

54. Meiyun Shi^#, Lei Yin^#, Yantong Sun, Can Wang, Lanlan Cai, Tinglan Zhang, Xiaotong Zhou, J Paul Fawcett, Xiaoli Gao, Jingkai Gu. Pharmacokinetic Study of Conjugated Equine Estrogens in Healthy Chinese Postmenopausal Women Using a Parallel Two-Column LC-MS/MS Method. Clin Pharmacokinet. 2022 Nov;61(11):1571-1583. JCR:Q1（PHARMACOLOGY & PHARMACY）并列一作,中科院药学1区TOP

53. Lei Yin, Tianming Ren, Shiying Zhao, Meiyun Shi, Jingkai Gu. Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique. Talanta. 2020,01;206:120184. SCI：000488416200009, JCR:Q1（CHEMISTRY, ANALYTICAL）, 中科院1区TOP

52. Wenhai Lin^#, Lei Yin^#, Tingting Sun, Tingting Wang, Zhigang Xie*, Jingkai Gu*, Xiabin Jing. The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules. 2018, 19(5):1625-1634. SCI：000432476800025, JCR:Q1（CHEMISTRY）, Q1（POLYMER SCIENCE）并列一作，中科院高分子科学1区

51. Meiyun Shi, Qiuhong Jiang, Di Lu, Xinyue Zheng, Xujian Duan, Xiangyi Xu, Yajun Liu, Hongyu Xue, Lei Yin. Quantitative analysis of polypropylene glycol polymers by liquid chromatography tandem mass spectrometry based on collision induced dissociation technique. J Chromatogr A. 2022, 1676:463214. JCR:Q1（CHEMISTRY, ANALYTICAL）通讯作者，中科院分析化学2区TOP

50. Xiangyi Xu, Xuanxi Jiang, Meiyun Shi, Lei Yin. Mass spectrometry-based techniques for single-cell analysis. Analyst. 2023, 148(16):3690-3707. 中科院分析化学2区，通讯作者

49. Lei Yin, Aiyun Xu, Yumeng Zhao, Jingkai Gu. Bioanalytical assays for pharmacokinetic and biodistribution study of Antibody-Drug Conjugates. Drug Metab Dispos, 2023, 51(10):1324-1331.中科院药学2区

48. Lei Yin, Zhi Zhang, Yingze Liu, Yin Gao, Jingkai Gu. Recent advances in single-cell analysis by mass spectrometry. Analyst. 2019,02;144(3):824-845. SCI：000457394400007,  JCR:Q1（CHEMISTRY, ANALYTICAL）中科院分析化学2区

47. Meiyun Shi, Xujian Duan, Xinyue Zheng, Di Lu, Yuncheng Ge, Ning Zhang, Yajun Liu, Jiansong You, Hongyu Xue, Lei Yin. Quantification of human serum albumin by combining chymotrypsin/trypsin digestion coupled with LC-MS/MS technique. Analytical Biochemistry. 2023, 680:115316. 通讯作者

46. Xujian Duan, Di Lu, Xinyue Zheng, Qiuhong Jiang, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin, Meiyun Shi. Development and validation of an LC-MS/MS assay with multiple stage fragmentation for the quantification of alachlor in McF-7 cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2023, 1214:123550. 并列通讯作者

45. Xinyue Zheng, Xujian Duan, Di Lu, Qiuhong Jiang, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin, Meiyun Shi. Cellular toxicity and pharmacokinetic study of butachlor by ultra-performance liquid chromatography-tandem mass spectrometry based on tandem mass spectrometry cubed technique. J Sep Sci. 2023 Jan;46(1):e2200725.并列通讯作者. JCR: Q2 (CHEMISTRY, ANALYTICAL).

44. 崔雨琪^#，雷芳彬^#，张霖茜，尤建嵩，尹磊，史美云。聚合物纳米药物制剂生物分析方法及药动学研究进展. 药学学报, Acta Pharmaceutica Sinica 2023, 58(4): 844−851. 通讯作者

43. 刘一^#，张煜杰^#，王梓榆，尤建嵩，尹磊，史美云。脂质体纳米药物制剂的生物分析方法及药代动力学研究进展，药学学报，Acta Pharmaceutica Sinica 2023, 58(4): 834−843. 通讯作者

42. Yin Lei, Su Chong, Ren Tianming, Meng Xiangjun, Shi Meiyun, Paul Fawcett J, Zhang Mengliang, Hu Wei, Gu Jingkai*. MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra. Analyst. 2017,11, 142(22):4279-4288. SCI：000414485800012,  JCR:Q1（CHEMISTRY, ANALYTICAL）中科院分析化学2区

41. Meiyun Shi, Qiuhong Jiang, Qiushi Lyu, Zhengting Yuan, Lili Deng, Lei Yin. A LC-MS3 strategy to determine lamotrigine by Q-Q-trap tandem mass spectrometry coupled with triple stage fragmentation to enhance sensitivity and selectivity. Anal Methods. 2021 Oct 8;13(38):4478-4484.通讯作者, JCR Q1（SPECTROSCOPY）, JCR Q2（CHEMISTRY, ANALYTICAL）

40. Lei Yin, Junfeng Yang, Xiangjun Meng, Bo Yang, Chong Su, Zhichao Yang, Mi Zheng, Limei Zhao, Jingkai Gu* and Guijie Xin*, An LC-MS/MS method to determine PABA and DIP, Analytical Methods, 2016,01; 8, 1013-1020. SCI：000369540600011,  JCR Q1（SPECTROSCOPY）, JCR Q2（CHEMISTRY, ANALYTICAL）

39. Meiyun Shi, Xinyue Zheng, Di Lu, Xujian Duan, Yongqi Wang, Yajun Liu, Hongyu Xue, Lei Yin. Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects. J Pharm Biomed Anal. 2022 May 30;214:114751. JCR Q2（CHEMISTRY, ANALYTICAL）中科院分析化学2区, 通讯作者

38. Wenbo Ren^#, Lei Yin^#, Gaixia Zhang, Taiyu Zhai, Jing Huang. Comparison of LC-MS3 and LC-MRM Method for quantifying voriconazole and its application in therapeutic drug monitoring of human plasma. Molecules. 2022 Aug 31;27(17):5609. JCR Q2（CHEMISTRY, MULTIDISCIPLINARY）中科院化学2区, 并列一作

37. Lei Yin, Yiling Pang, Lin Shan, Jingkai Gu. The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems. Drug Metab Dispos. 2022, 50(6):827-836.中科院药学2区

36. Lei Yin, Zhengchao Ji, Haiwei Cao, Yanyan Li, Jing Huang. Comparison of LC-MS3 and LC-MRM strategy for quantification of methotrexate in human plasma and its application in therapeutic drug monitoring. J Pharm Biomed Anal. 2021 Oct 25;205:114345. JCR Q2（CHEMISTRY, ANALYTICAL）中科院分析化学2区

35. Dongxiao Ma, Zhengchao Ji, Haiwei Cao, Jing Huang, Lei Zeng, Lei Yin. LC-MS3 Strategy for Quantification of Carbamazepine in Human Plasma and Its Application in Therapeutic Drug Monitoring. Molecules. 2022 Feb 11;27(4):1224. 通讯作者, Q2（BIOCHEMISTRY & MOLECULAR BIOLOGY）中科院化学2区, 通讯作者

34. Zhengchao Ji^#, Lei Yin^#, Yanyan Li, Xiaoquan Yang, Lin Lin, Lingling Liu, Yi Jiang, Jing Huang. Development and validation of a liquid chromatography-tandem mass spectrometry method with triple-stage fragmentation to determine levetiracetam in epileptic patient serum and its application in therapeutic drug monitoring. J Sep Sci. 2021 Dec;44(23):4255-4263.并列一作. JCR: Q2 (CHEMISTRY, ANALYTICAL).

33. Haiwei Cao^#, Lei Yin^#, Haihuan Cao, Haiyang Guo, Wenbo Ren, Yanyan Li, Jing Huang. A sensitive and selective HPLC-MS3 method for therapeutic drug monitoring of meropenem and its validation by comparison with HPLC-MS2 methods. J Sep Sci. 2022 May;45(10):1683-1692.并列一作. JCR: Q2 (CHEMISTRY, ANALYTICAL).

32. Lei Yin, Yixuan Feng, Jin Tong, Zhiqiong Guo, Yuyao Zhang, Qi Zhang, Yantong Sun, Fawcett JP, Jingkai Gu. Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study. Anal Bioanal Chem. 2019,08;411(20):5139-5148. SCI：000475515600013,中科院分析化学2区

31. Lei Yin, Meiyun Shi, Tingting Wang, Miaomin Zhang, Xiaojun Zhao, Ying Zhang, Jingkai Gu*, A Parallel-Column LC–MS/MS Method for High-Throughput Analysis of Eight Antiepileptic Drugs in Clinical Therapeutic Drug Monitoring, Chromatographia, 2017,01,137-143. SCI：000392315400017, JCR:Q3（CHEMISTRY, ANALYTICAL）

30. Lei Yin^#, Tingting Wang^#,Meiyun Shi^#,Ying Zhang,Xiaojun Zhao,Yan Yang*, Jingkai Gu*, Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in therapeutic drug monitoring, J. Sep. Sci. 2016,03;39(5):964-72. SCI：000372280600021, JCR:Q2（CHEMISTRY, ANALYTICAL）

29. Lei Yin, Xiangjun Meng, Xiaotong Zhou, Tinglan Zhang, Heping Sun, Zhichao Yang，Bo Yang, Ning Xiao, J. Paul Fawcett, Yan Yang, Jingkai Gu*, Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography–tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study, Journal of Chromatography B, 2015.08; 998, 8–14. SCI：000359957100002, JCR:Q2（BIOCHEMICAL RESEARCH METHODS）, Q2（CHEMISTRY, ANALYTICAL）

28. Lei Yin, Meiyun Shi,Yantong Sun, Xiaocheng Sun, Huan Meng, J.Paul Fawcett, Yan Yang*, Jingkai Gua*. A liquid chromatography–tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study. Journal of Chromatography B, 2013,06; 931,12–16. SCI：000321593900003, JCR:Q2（BIOCHEMICAL RESEARCH METHODS）, Q2（CHEMISTRY, ANALYTICAL）

27. Lei Yin, Yun-hui Zhang, Sen Zhao, Long-mei Cheng, Mei-yun Shi, Yan Yang*, Yan-tong Sun*, Xi-dong Liu, J.Paul Fawcett. Rapid quantification of astilbin in rat plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Chemical Research in Chinese Universities. 2013,12; 29,1078-1082. SCI：000329095200012, JCR:Q3（CHEMISTRY, MULTIDISCIPLINARY）

26. Shi Meiyun, Zhao Xiaojun, Wang Tingting, Yin Lei, Li Yanyan. A LC-MS-MS assay for simultaneous determination of two glycopeptides and two small molecule compounds in human plasma. J Chromatogr Sci. 2018, 10; 1;56(9):828-834. 通讯作者.

25. Meiyun Shi, Mengyao Xu, Lei Yin*, Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats. J Pharm Pharmacol. 2020 Aug;72(8):1061-1071. 通讯作者. JCR:Q2 (PHARMACOLOGY & PHARMACY).

24. Shi M, Jiang H, Yin L, Liu Y, Xu M. Development of an UPLC-MS/MS method coupled with in-source CID for quantitative analysis of PEG-PLA copolymer and its application to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 1;1125:121716. JCR:Q2（BIOCHEMICAL RESEARCH METHODS）, Q2（CHEMISTRY, ANALYTICAL）.

23. Wang T, Yin L, Wang H, Fawcett JP, Gu J. Development and application of a high-throughput liquid chromatography-tandem mass spectrometric method for the simultaneous determination of thymosin α1 and its recombinant human form in plasma and urine. J Pharm Biomed Anal. 2019, 170:16-21. 中科院分析化学2区

22. Xiaojiao Li, Yantong Sun, Lei Yin, Xueju Zhang, YanYang, J. paul Fawcettc, Yimin Cui, and Jingkai Gu. Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LC-MS/MS: method development, validation and application to pharmacokinetics. Journal of Pharmaceutical Analysis, 2013, 3(1):1-8. 中科院药学1区

21. Yunhui Zhang, Yantong Sun, Guoqing Li, Lei Yin, et al. Determination of Prostaglandin E1 in dog plasma using liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Journal of Chromatography B, 2013, 937:97–102. JCR:Q2 (BIOCHEMICAL RESEARCH METHODS), Q2 (CHEMISTRY, ANALYTICAL).

20. Xiangyong Cui, Mengliang Zhang , Xin Guan, Lei Yin, Yantong Sun, J. Paul Fawcett , Jingkai Gu. LC–MS–MS determination of troxerutin in plasma and its application to a pharmacokinetic study. Chromatographia , 2011, 73:165–169. JCR: Q3 (CHEMISTRY, ANALYTICAL)

19. Su Chong, Sun Hui, Yang Hong, Yin Lei, Zhang Jiwen, Fawcett JP, Gu Jingkai. A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study. Anal Bioanal Chem. 2017, 409(28):6559-6565. JCR: Q2 (CHEMISTRY, ANALYTICAL), Q2 (BIOCHEMICAL RESEARCH METHODS). 中科院分析化学2区

18. Lu Huan, Su Chong, Yin Lei, Gu Liqiang, Gu Jingkai, Chen Xiaohui. Liquid chromatography-tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma. Journal of Pharmaceutical Analysis, 2016, 6(2):112-116. JCR: Q1 (PHARMACOLOGY & PHARMACY). 中科院药学1区

17. Chen H, Zhang Q, Li X, Zhang H, Sun Y, Yin L, Liu C, Cao Y, Gu J, Ding Y. Single and multiple-dose pharmacokinetics and tolerability of limaprost in healthy Chinese subjects. Clin Drug Investig. 2015, 35(3):151-7. JCR: Q3 (PHARMACOLOGY & PHARMACY).

16. Feng B, Zhu H, Guan J, Zhao L, Gu J, Yin L, Fawcett JP, Liu W. A rapid and sensitive UFLC-MS/MS method for the simultaneous determination of gentiopicroside and swertiamarin in rat plasma and its application in pharmacokinetics. J Pharm Pharmacol. 2014, 66(10):1369-76. JCR: Q2(PHARMACOLOGY & PHARMACY).

15. Shi Meiyun, Lei Yin, CAI Lanlan, WANG Can，LIU Xidong，ZHAO Sen，SUN Yantong，FAWCETT J. Paul，ZHAO Limei，YANG Yan(*)，GU Jingkai(*)，LC-MS/MS Method for the Quantitation of Cefotetan in Human Plasma and Its Application to Pharmacokinetic Study，Chemical Research in Chinese Universities, 2014, 30(6):900-904.JCR: Q3(CHEMISTRY, MULTIDISCIPLINARY).

14.姜翠,吴瑞红,王晓美,尹磊,尹沛源,迟秀梅,顾景凯,潘煜,许国旺.丙型肝炎自发清除者的血清代谢组学研究. 中华传染病杂志，2013, 31(2)：32-37

13. 张荣，顾景凯，尹磊，陈灵，王朝霞HPLC-MS/MS法检测吉林省427例儿童血浆25(OH)D的水平[J]. 中国妇幼保健，2013,28(2),320-322.

12. LC-Triple TOFTM 快速筛查血浆样本中2500种毒物药物。2012，第十届全国药物与化学异物代谢学术会议暨第三届ISSX/CSSX联合学术会议青年论坛优秀论文。

11. 液相色谱高分辨率质谱法快速鉴定大鼠体内川丁特罗的代谢产物. 2012，第十届全国药物与化学异物代谢学术会议。

10. 黄芩素及其四种主要代谢产物人体药代动力学分析方法研究. 第十届全国药物与化学异物代谢学术会议。

9. Yang C, Song W, Zhang D, Yu H, Yin L, Shen N, Deng M, Tang Z, Gu J, Chen X. Poly (l-glutamic acid)-g-methoxy poly (ethylene glycol)-gemcitabine conjugate improves the anticancer efficacy of gemcitabine. Int J Pharm. 2018 Oct 25;550(1-2):79-88. 2018 Aug 20. JCR: Q1 (PHARMACOLOGY & PHARMACY).

8. Liang C, Sun H, Meng X, Yin L, Fawcett JP, Yu H, Liu T, Gu J. Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry. Acta Pharm Sin B. 2018, 8(2):228-234. 中科院药学1区.

7. Wang D, Li W, Zou Q, Yin L, Du Y, Gu J, Suo J. Serum metabolomic profiling of human gastric cancer and its relationship with the prognosis. Oncotarget. 2017 Sep 28;8(66):110000-110015. doi: 10.18632/oncotarget.21314. eCollection 2017 Dec 15.

6. Daguang Wang, Wei Li, Lei Yin, Yechao Du, Shaopeng Zhang, Jian Suo. Association of serum levels of deoxyribose-1-phosphate and S-lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study. ONCOLOGY LETTERS 19: 2231-2242, 2020. JCR: Q3 (ONCOLOGY).

5. Xin Guan, Lei Yin, Yan Yang, Xiang-Jun Meng, De-Li Wang, Yan-Tong Sun. Quantitation of lovastatin and its hydroxy acid in human plasma by high-performance liquid chromatography-tandem mass spectrometry, Journal of Liquid Chromatography & Related Technologies,2018, 41:10, 668-675, DOI: 10.1080/10826076.2018.1508473.

4. Zhi Zhang, Yuyao Zhang, Shiwen Song, Lei Yin, Dong Sun, Jingkai Gu. Recent advances in the bioanalytical methods of polyethylene glycols and pegylated pharmaceuticals, J Sep Sci. 2020 Feb 20. doi: 10.1002/jssc.201901340. JCR: Q2 (CHEMISTRY, ANALYTICAL).

3. Leonardi A, Kovalchuk N, Yin L, Endres L, Evke S, Nevins S, Martin S, Dedon PC, Melendez JA, Van Winkle L, Zhang QY, Ding X, Begley TJ. The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene. Epigenetics. 2020 Apr 17:1-18. doi: 10.1080/15592294.2020.1750213. JCR: Q1(GENETICS & HEREDITY).

2. Man Yang, Chenyao Li, Yajing Li, Chen Cheng, Meiyun Shi, Lei Yin, Hongyu Xue, Yajun Liu. Design, synthesis, biological evaluation and molecular docking study of 2,4-diarylimidazoles and 2,4-bis(benzyloxy)-5-arylpyrimidines as novel HSP90 N-terminal inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2551-2565. JCR: Q1(CHEMISTRY, MEDICINAL).

1. Jacklyn Kelty, Nataliia Kovalchuk, Eric Uwimana, Lei Yin, Xinxin Ding , Laura Van Winkle. In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 1;323(3):L308-L328. JCR: Q1(PHYSIOLOGY).

申请专利具体如下：

1. 一种生物样本中PEG 化药物的定量测定方法,（ZL 201610031386.1）

2. 一种生物样本中PEG 含量的测定方法,（ZL 201510356323.9）

3. 一种PEG及PEG化药物的分析检测方法及其应用（ZL 201710706546.2）

4. 一种定量测定生物样品中前列腺素的方法(ZL 201710707523.3)

5. 一种脑靶向艾司利卡西平酯类前药及其应用(ZL201611039363.1)