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论文类型：期刊论文

发表时间：2015-01-01

发表刊物：Cancer Informatics

收录刊物：Scopus

卷号：14

页面范围：57-67

ISSN号：11769351

摘要：Deep sequencing has recently emerged as a powerful alternative to microarrays for the high-throughput profiling of gene expression. In order to account for the discrete nature of RNA sequencing data, new statistical methods and computational tools have been developed for the analysis of differential expression to identify genes that are relevant to a disease such as cancer. In this paper, it is thus timely to provide an overview of these analysis methods and tools. For readers with statistical background, we also review the parameter estimation algorithms and hypothesis testing strategies used in these methods. ? the authors, publisher and licensee Libertas Academica Limited.