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个人信息Personal Information
副教授
博士生导师
硕士生导师
性别：男
毕业院校：中国协和医科大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 微生物学. 微生物与生化药学
办公地点：辽宁省大连市高新园区凌工路2号大连理工大学西部校区生物工程学院309室
联系方式：辽宁省大连市高新园区凌工路2号大连理工大学生物工程学院
电子邮箱：yshdong@dlut.edu.cn
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Cathepsin B Inhibitory Tetraene Lactones from the Fungus Talaromyces wortmannii
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论文类型：期刊论文
发表时间：2009-03-01
发表刊物：HELVETICA CHIMICA ACTA
收录刊物：SCIE、EI、Scopus
卷号：92
期号：3
页面范围：567-574
ISSN号：0018-019X
摘要：Wortmannilactones E-H (1-4), four new cathepsin B inhibitors, were produced and isolated from the culture of the soil filamentous fungus Talaromyces wortmannii, Their structures and relative configurations were elucidated on the basis of 1D- and 2D-NMR techniques, three of them (1, 2, and 4) posses an oxabicyclo[2.2.1]heptane moiety. Compounds 1-4 showed inhibitory activities against cathepsin B with IC(50) values of 4.3, 6.5, 13.0, and 6.0 mu M, respectively.