Jiannan Zhao received his B.S. in Chemistry from Sichuan University in 2010. Then he stayed there and pursued his PhD in Chemistry with Prof. Xiaoming Feng. His thesis work involved asymmetric Mannich reaction of silyl ketene imines catalyzed by N,N’-dioxide-metal complexes. Upon graduation in 2015, Jiannan joined the laboratory of Prof. Ohyun Kwon at the University of California, Los Angeles as a postdoctoral fellow. There, he completed an intramolecular crossed [2+2] cycloadditions of dienones. Jiannan joined the faculty in Zhang Dayu School of Chemistry at Dalian University of Technology in 2018. His research mainly focused on the development of novel radical-mediated reactions and asymmetric synthesis.

Publications：

[18]  Chuyu Xiao,^# Jing-Ran Shan,^# Wen-Deng Liu, Xingyuan Gao, Jingwei Dai, Zuwei Wang, Wentao Wang, K. N. Houk,* Jiannan Zhao* "Stereoselective Radical Acylfluoroalkylation of Bicyclobutanes via N-Heterocyclic Carbene Catalysis" Angew. Chem. Int. Ed., 2024, accepted, DOI:10.1002/anie.202416781.

[17]  Wen-Deng Liu, Jiyuan Gao, Jia-Nan Mo, Yuqiao Zhou,* Jiannan Zhao* "Cooperative NHC and Photoredox Catalyzed Radical Aminoacylation of Alkenes to Tetrahydropyridazines" Chem. Eur. J. 2024, 30, e202402288. (Invited Paper)

        Published as part of Special Collection "Chirality: From Small Molecules to Macromolecules"

[16]  Jia-Nan Mo, Shengbin Sun, Huiwei Xu, Hanyu Shu, Jiannan Zhao* "Synthesis of γ‑Oxo-phosphonates via N‑Heterocyclic CarbeneCatalyzed Acylphosphorylation of Alkenes" Org. Lett. 2024, 26, 2197−2201.

         Published as part of Virtual Special Issue "Radical Reactions for the Construction and Transformation of Complex Molecules"

[15]  Hanyu Shu^#, Jia-Nan Mo^#, Wen-Deng Liu, Jiannan Zhao* "Synthesis of Pyrroloindolines via N‑Heterocyclic Carbene Catalyzed Dearomative Amidoacylation of Indole Derivatives"  Org. Lett. 2023, 25, 8677−5584.

[14]  Junqi Su, Aobo Chen, Guofeng Zhang, Ziyu Jiang, Jiannan Zhao* "Photocatalytic Phosphine-Mediated Thioesterification of Carboxylic Acids with Disulfides" Org. Lett. 2023, 25, 8033−8037.

[13]  Junqi Su, Jia-Nan Mo, Guofeng Zhang, Ziyu Jiang, Jiannan Zhao* "A Practical Approach for Oligopeptide Synthesis via Synergistic Photoredox, Cobaloxime and Organophosphorus Triple Catalysis" Org. Chem. Front. 2023, 10, 4895−4904.

        Highlighted by Synfacts 2024, 20, 105.

[12]  Huiwei Xu, Wanyao Zheng, Wen-Deng Liu, Yuqiao Zhou,* Luqing Lin, Jiannan Zhao* "Silylacylation of Alkenes through N‑Heterocyclic Carbene Catalysis" Org. Lett. 2023, 25, 5579−5584.

[11]   Wencheng Han, Wen-Deng Liu, Junqi Su, Jiannan Zhao* "Deoxygenation of Oximes for the Synthesis of Pyrrolines via Hydroimination Cyclization" Org. Biomol. Chem. 2023, 21, 3350−3354.

[10]  Huiwei Xu, Jia-Nan Mo, Wen-Deng Liu, Jiannan Zhao* "N-Heterocyclic Carbene-Catalyzed Remote C(sp³)–H Acylation of Amides" Tetrahedron Lett. 2023, 121, 154483.

[9]  Wen-Deng Liu^#, Woojin Lee^#, Hanyu Shu, Chuyu Xiao, Huiwei Xu, Xiangyang Chen, Kendall N. Houk*, Jiannan Zhao* "Diastereoselective Radical Aminoacylation of Olefins through N-Heterocyclic Carbene Catalysis" J. Am. Chem. Soc. 2022, 144, 22767−22777. 

       Highlighted by Synfacts 2023, 19, 183.

[8]  Wencheng Han, Junqi Su, Jia-Nan Mo, Jiannan Zhao* "Photoredox Catalytic Phosphine-Mediated Deoxygenation of Hydroxylamines Enables the Construction of N-Acyliminophosphoranes" Org. Lett. 2022, 24, 6247−6251.

[7]   Jiannan Zhao Introducing... Angew. Chem. Int. Ed. 2022, 61, e202116270.

[6] Junqi Su, Jia-Nan Mo, Xiangyang Chen, Alexander Umanzor, Zheng Zhang, Kendall N. Houk, Jiannan Zhao* “Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow” Angew. Chem. Int. Ed., 2022, 61, e202112668. (Hot Paper, Cover)

[5]   Jia-Nan Mo, Junqi Su, Jiannan Zhao* "The Asymmetric A³(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines" Molecules 2019, 24, 1216.

[4]    Jiannan Zhao, Jonathan L. Brosmer, Qingxuan Tang, Zhongyue Yang, K. N. Houk, Paula L. Diaconescu, Ohyun Kwon*“Intramolecular Crossed [2+2] Photocycloaddition through Visible Light-Induced Energy Transfer”J. Am. Chem. Soc. 2017, 139, 9807−9810.

[3]    Jiannan Zhao, Bing Fang, Weiwei Luo, Xiaoyu Hao, Xiaohua Liu, Lili Lin, and Xiaoming Feng* “Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines”Angew. Chem. Int. Ed., 2015, 54, 241–244.

[2]    Jiannan Zhao, Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Lili Lin, and Xiaoming Feng* “Asymmetric Synthesis of β-Amino Nitriles through a Sc^III-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines”Angew. Chem. Int. Ed., 2013, 52, 3473–3477.

[1]   Jiannan Zhao, Ke Zheng, Yang Yang, Jian Shi, Lili Lin, Xiaohua Liu, Xiaoming Feng*“Asymmetric Mukaiyama Aldol Reaction Catalyzed by C₂-Symmetric N,N'-Dioxide–Ni(II) Complex”Synlett, 2011, 903–906. 

Book Chapters:

Jiannan Zhao, Shunxi Dong, Xiaoming Feng*, "[4+2]-Cycloadditions (Inverse-Electron-Demand Hetero-Diels-Alder Reaction)" Elsevier, DOI:10.1016/B978-0-32-390644-9.00002-0.