Dr Zhu is a professor at the School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology. He is a doctoral supervisor, a recipient of the National Young Talents Program, and recognized as a high-level talent in Dalian. He received his bachelor's degree from Wuhan University in 2010 and his Ph.D. from the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences in 2015, under the supervision of Academician Erkang Wang. From 2016 to 2023, he conducted postdoctoral research at the Cavendish Laboratory, University of Cambridge, under the supervision of Professor Ulrich Keyser.
Dr. Zhu joined the Faculty of Medicine at Dalian University of Technology in April 2023, focusing on research and applications in life and medical analysis based on nucleic acids. His work primarily utilizes solid-state nanopore single-molecule detection methods, combined with molecular interaction and recognition tools such as metal-organic cages, to detect disease-related specific nucleic acid sequences and identify single-base mismatches. To date, he has published 53 academic papers, including 22 as first or corresponding author in journals such as J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., Nano Lett., ACS Nano, Chem. Sci., Small, Adv. Funct. Mater., and Biomaterials, etc.
Our research group is recruiting graduate students and postdoctoral researchers. We conduct interdisciplinary research, and we welcome young talents with backgrounds in biology, medicine, physics, chemistry, or engineering who are passionate about scientific research to join us. The group maintains strong collaborative relationships with leading universities and research institutions in Europe and North America, including the University of Cambridge. Outstanding graduate students and postdoctoral researchers may be recommended for joint training opportunities at overseas universities and institutions.
Publications in recent years:
(1) Yunxuan Li, Sarah E. Sandler, Ulrich F. Keyser*, and Jinbo Zhu*, DNA Volume, Topology, and Flexibility Dictate Nanopore Current Signals. Nano Letters 2023, 23, 7054-7061.
(2) Jinbo Zhu, Ran Tivony, Filip Bošković, Joana Pereira-Dias, Sarah E. Sandler, Stephen Baker, Ulrich F. Keyser*, Multiplexed nanopore-based nucleic acid sensing and bacterial identification using DNA dumbbell nanoswitches. Journal of the American Chemical Society 2023, 145, 2115-12123.
(3) Filip Bošković, Jinbo Zhu, Ran Tivony, Alexander Ohmann, Kaikai Chen, Mohammed F. Alawami, Milan Đorđević, Niklas Ermann, Joana Pereira-Dias, Michael Fairhead, Mark Howarth, Stephen Baker, Ulrich F. Keyser*, Simultaneous identification of viruses and SARS-CoV-2 variants with programmable DNA nanobait. Nature Nanotechnology, 2023, 18, 290-298.
(4) Jinbo Zhu, Filip Bošković, Ulrich F. Keyser*, Split G-quadruplexes enhance nanopore signals for simultaneous identification of multiple nucleic acids. Nano Letters 2022, 22, 4993-4998.
(5) Yesheng Wang, Zhentong Zhu, Chunmiao Yu, Ruiping Wu, Jinbo Zhu*, Bingling Li*, Lego-like Catalytic Hairpin Assembly Enables Controllable DNA-Oligomer Formation and Spatiotemporal Amplification in Single Molecular Signaling. Small 2022, 19, 2206283.
(6) Jinbo Zhu, Filip Bošković, Bao-Nguyen T. Nguyen, Jonathan R. Nitschke*, Ulrich F. Keyser*, Kinetics of Toehold-Mediated DNA Strand Displacement Depend on FeII4L4 Tetrahedron Concentration. Nano Letters 2021, 21, 1368-1374.
(7) Jinbo Zhu, Niklas Ermann, Kaikai Chen, Ulrich F. Keyser*, Image Encoding Using Multi‐Level DNA Barcodes with Nanopore Readout, Small 2021, 17, 2100711.
(8) Jinbo Zhu, Zhiqiang Yan, Filip Bošković, Cally J. E. Haynes, Marion Kieffer, Jake L. Greenfield, Jin Wang, Jonathan R. Nitschke*, Ulrich F. Keyser*, FeII4L4 tetrahedron binds and aggregates DNA G-quadruplexes. Chemical Science 2021, 12, 14564-14569.
(9) Jinbo Zhu, Cally J. E. Haynes, Marion Kieffer, Jake L. Greenfield, Ryan D. Greenhalgh, Jonathan R. Nitschke*, Ulrich F. Keyser*, FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases. Journal of the American Chemical Society 2019, 141, 11358-11362.
(10) Jinglin Kong‡, Jinbo Zhu‡, Kaikai Chen, Ulrich F. Keyser*, Specific Biosensing Using DNA Aptamers and Nanopores. Advanced Functional Materials 2019, 29, 1807555. (‡co-first authors)
(11) Cally J. E. Haynes‡, Jinbo Zhu‡, Catalin Chimerel, Silvia Hernandez-Ainsa, Imogen A. Riddell, Tanya K. Ronson, Ulrich F. Keyser*, Jonathan R. Nitschke*, Blockable Zn10L15 Ion Channels through Subcomponent Self-Assembly. Angewandte Chemie International Edition 2017, 48, 15388-15392. (‡co-first authors)
As the carrier of genetic information, nucleic acids hold vital biological information for living organisms. Detecting nucleic acid fragments in bodily fluids could enable early screening of major diseases and rapid diagnosis of infectious diseases. As a commonly used and important method for biomedical information analysis, the development of nucleic acid detection technology is closely related to fields such as bioinformatics, clinical medicine, food safety, disease screening, and epidemic prevention and control. Our work mainly focuses on the following two areas.
(1) Nanopore-based nucleic acid sensing and its application
Compared to protein-based biological nanopores, capillary glass solid-state nanopores offer controllable dimensions and stable properties, presenting significant potential for biomolecular analysis. We have incorporated various DNA nanostructures and DNA strand displacement reactions into this nanopore detection platform. Using DNA nanostructures instead of protein labels, we have achieved parallel detection of multiple nucleic acid sequences, single-base mutation identification, DNA parallel circuit readout, as well as virus and bacteria differentiation. Additionally, we have developed an editable and encryptable DNA information storage system based on nanopore readout.
(2) Interaction between Metal-Organic Cages (MOCs) and nucleic acids
MOC materials possess many unique properties and significant potential for biomedical applications. However, it remains unclear which types of MOC molecules are suitable for biological applications and what principles govern their interactions with biomolecules. Against this backdrop, we have explored and established a set of principles governing the interactions between a class of MOCs and DNA. We have applied this knowledge as a novel tool for nucleic acid recognition, enabling single-base mismatch detection, regulation of strand displacement reaction kinetics, and control of G-quadruplex aggregation and enzymatic cleavage reactions.
Changchun Institute of Applied Chemistry, Chinese Analytical Chemistry PhD
Wuhan University Chemical Biology Bachelor's Degree
Shashi Middle School in Hubei province \
Dalian University of Technology School of Biomedical Engineering, Faculty of Medicine 教授 Professor
University of Cambridge Cavendish Laboratory Postdoc
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