个人信息Personal Information
教授
博士生导师
硕士生导师
性别:男
毕业院校:大连理工大学
学位:博士
所在单位:计算机科学与技术学院
电子邮箱:yangzh@dlut.edu.cn
A graph kernel based on context vectors for extracting drug-drug interactions
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论文类型:期刊论文
发表时间:2016-06-01
发表刊物:JOURNAL OF BIOMEDICAL INFORMATICS
收录刊物:SCIE、EI、PubMed
卷号:61
页面范围:34-43
ISSN号:1532-0464
关键字:Context vector; Graph kernel; Equivalent class; Drug-drug interactions
摘要:The clinical recognition of drug-drug interactions (DDIs) is a crucial issue for both patient safety and health care cost control. Thus there is an urgent need that DDIs be extracted automatically from biomedical literature by text-mining techniques. Although the top-ranking DDIs systems explore various features of texts, these features can't yet adequately express long and complicated sentences. In this paper, we present an effective graph kernel which makes full use of different types of contexts to identify DDIs from biomedical literature. In our approach, the relations among long-range words, in addition to close-range words, are obtained by the graph representation of a parsed sentence. Context vectors of a vertex, an iterative vectorial representation of all labeled nodes adjacent and nonadjacent to it, adequately capture the direct and indirect substructures' information. Furthermore, the graph kernel considering the distance between context vectors is used to detect DDIs. Experimental results on the DDIExtraction 2013 corpus show that our system achieves the best detection and classification performance (F-score) of DDIs (81.8 and 68.4, respectively). Especially for the Medline-2013 dataset, our system outperforms the top-ranking DDIs systems by F-scores of 10.7 and 12.2 in detection and classification, respectively. (C) 2016 Elsevier Inc. All rights reserved.