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个人信息Personal Information
高级工程师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学
办公地点：理工西部校区实验楼F308
联系方式：rzhang@dlut.edu.cn
电子邮箱：rzhang@dlut.edu.cn
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Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease
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论文类型：期刊论文
发表时间：2009-08-01
发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
收录刊物：SCIE、PubMed、Scopus
卷号：19
期号：15
页面范围：4139-4142
ISSN号：0960-894X
关键字：Bisintercalator; Dinuclear Iron(III) complex; Artificial nuclease
摘要：Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage. (C) 2009 Elsevier Ltd. All rights reserved.