点击次数：
论文类型：期刊论文
发表时间：2015-04-01
发表刊物：APPLIED MATHEMATICAL MODELLING
收录刊物：SCIE、EI
卷号：39
期号：7
页面范围：2036-2047
ISSN号：0307-904X
关键字：Nonlinear switching system; Two-phase method; Parametric sensitivity functions; Optimization algorithm; Microbial continuous fermentation
摘要：To describe the continuous bioconversion of glycerol to 1,3-propanediol concerning the intracellular and extracellular dynamics and the transports across cell membrane, we establish a nonlinear switching system and discuss its some basic properties. For this over parameterized dynamical system, we propose a two-phase method to determine its parameters. The first phase carries out parametric sensitivity analysis for the purpose of reducing the number of the unknown parameters and the second phase covers the optimization of those parameters with higher sensitivity index. Numerical calculations on the basis of multi-groups experiments indicate that the proposed switching system is appropriate and the developed methods are valid. (C) 2014 Elsevier Inc. All rights reserved.