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论文类型：期刊论文
发表时间：2014-10-01
发表刊物：JOURNAL OF PROCESS CONTROL
收录刊物：SCIE、EI、Scopus
卷号：24
期号：10
页面范围：1556-1569
ISSN号：0959-1524
关键字：Optimal control; Hybrid system; Inequality path constraint; Parametric sensitivity system; Optimization algorithm
摘要：A nonlinear hybrid system was proposed to describe the fed-batch bioconversion of glycerol to 1,3-propanediol with substrate open loop inputs and pH logic control in previous work [47]. The current work concerns the optimal control of this fed-batch process. We slightly modify the hybrid system to provide a more convenient mathematical description for the optimal control of the fed-batch culture. Taking the feeding instants and the terminal time as decision variables, we formulate an optimal control model with the productivity of 1,3-propanediol as the performance index. Inequality path constraints involved in the optimal control problem are transformed into a group of end-point constraints by introducing an auxiliary hybrid system. The original optimal control problem is associated with a family of approximation problems. The gradients of the cost functional and the end-point constraint functions are derived from the parametric sensitivity system. On this basis, we construct a gradient-based algorithm to solve the approximation problems. Numerical results show that the productivity of 1,3-propanediol can be increased considerably by employing our optimal control policy. (C) 2014 Elsevier Ltd. All rights reserved.