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发布时间：2019-03-09
论文类型：期刊论文
发表时间：2009-11-01
发表刊物：NONLINEAR ANALYSIS-HYBRID SYSTEMS
收录刊物：Scopus、EI、SCIE
卷号：3
期号：4
页面范围：455-462
ISSN号：1751-570X
关键字：Batch culture; Specific rate of cell growth; Nonlinear dynamical system; Parameters identification
摘要：The bioconversion of glycerol to 1,3-propanediol is a complex bioprocess. In this study, we aim to explore a novel model for describing the multistage cell growth in batch culture. This is achieved by a modification at the specific rate of cell growth in consideratior of its time-dependent changes. The existence, uniqueness and boundedness of solutions to the system and the continuity of solutions with respect to the parameters are discussed. In addition, a parameter identification problem of the system is developed and a feasible optimization algorithm is constructed to solve it. Numerical result shows that the improved model could describe the batch culture well. (C) 2009 Elsevier Ltd. All rights reserved.