高占先
Professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Gender:Male
Alma Mater:大连工学院
Degree:Master's Degree
School/Department:化学系
E-Mail:zxgao001@dlut.edu.cn
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Indexed by:期刊论文
Date of Publication:2016-01-01
Journal:GREEN CHEMISTRY
Included Journals:SCIE
Volume:18
Issue:20
Page Number:5493-5499
ISSN No.:1463-9262
Abstract:An efficient and enantioselective photo-organocatalytic alpha-hydroxylation of beta-dicarbonyl compounds using molecular oxygen was extended. This simple catalytic procedure is applicable to a range of beta-keto esters and beta-keto amides (30 examples) with a new series of C-2'-substituted phase transfer catalysts in good enantiopurity (up to 90% ee) and yield (up to 99%). Moreover, the reaction was successfully scaled up to gram quantity without any loss of enantioselectivity.
