高占先
Professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Gender:Male
Alma Mater:大连工学院
Degree:Master's Degree
School/Department:化学系
E-Mail:zxgao001@dlut.edu.cn
Hits:
Indexed by:期刊论文
Date of Publication:2010-12-01
Journal:EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Included Journals:SCIE、Scopus
Issue:34
Page Number:6525-6530
ISSN No.:1434-193X
Key Words:Asymmetric catalysis; Phase-transfer catalysis; Hydroxylation; beta-Oxo esters
Abstract:The first enantioselective direct alpha-hydroxylation of beta-oxo esters was developed by using phase-transfer catalysis. 1-Indanone-derived 1-adamantyl (1-Ad) beta-oxo esters, in the presence of commercially available cumyl hydroperoxide and a cinchonine-based ammonium salt, resulted in the corresponding products with 69-91% yield and 65-74% ee. The reaction had also been successfully scaled-up to a gram quantity, and a similar yield was obtained without loss of the enantioselectivity.
