高占先
Professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Gender:Male
Alma Mater:大连工学院
Degree:Master's Degree
School/Department:化学系
E-Mail:zxgao001@dlut.edu.cn
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Indexed by:期刊论文
Date of Publication:2009-10-01
Journal:SYNLETT
Included Journals:SCIE、Scopus
Issue:16
Page Number:2659-2662
ISSN No.:0936-5214
Key Words:lappaconitine; asymmetric alpha-hydroxylation; beta-keto esters; organocatalyst; terpenoid alkaloid
Abstract:Discovering organocatalysts with novel framework from terpenoid alkaloids is presented in this paper. Lappaconitine was found to enantioselectively catalyze alpha-hydroxylation of beta-keto esters using tert-butyl hydroperoxide as the oxidant in chloroform to afford the corresponding products in high yields and good enantioselectivity (up to 85% ee).
