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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连工学院
学位：硕士
所在单位：化学系
电子邮箱：zxgao001@dlut.edu.cn
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A Series of Cinchona-Derived N-Oxide Phase-Transfer Catalysts: Application to the Photo-Organocatalytic Enantioselective alpha-Hydroxylation of beta-Dicarbonyl Compounds
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论文类型：期刊论文
发表时间：2016-08-19
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
收录刊物：SCIE、EI、PubMed、Scopus
卷号：81
期号：16
页面范围：7042-7050
ISSN号：0022-3263
摘要：A series of cinchona-derived N-oxide asymmetric phase-transfer catalysts were synthesized and applied in the enantioselective photo-organocatalytic alpha-hydroxylation of beta-keto esters and beta-keto amides (23 examples) using molecular oxygen in excellent yields (up to 98%) and high enantioselectivities (up to 83% ee). These new catalysts could be recycled and reused six times for such a reaction with almost the original reactivity and enantioselectivity.