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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连工学院
学位：硕士
所在单位：化学系
电子邮箱：zxgao001@dlut.edu.cn
扫描关注
Photo-organocatalytic enantioselective alpha-hydroxylation of beta-keto esters and beta-keto amides with oxygen under phase transfer catalysis
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论文类型：期刊论文
发表时间：2016-01-01
发表刊物：GREEN CHEMISTRY
收录刊物：SCIE
卷号：18
期号：20
页面范围：5493-5499
ISSN号：1463-9262
摘要：An efficient and enantioselective photo-organocatalytic alpha-hydroxylation of beta-dicarbonyl compounds using molecular oxygen was extended. This simple catalytic procedure is applicable to a range of beta-keto esters and beta-keto amides (30 examples) with a new series of C-2'-substituted phase transfer catalysts in good enantiopurity (up to 90% ee) and yield (up to 99%). Moreover, the reaction was successfully scaled up to gram quantity without any loss of enantioselectivity.