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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连工学院
学位：硕士
所在单位：化学系
电子邮箱：zxgao001@dlut.edu.cn
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Enantioselective alpha-chlorination of beta-oxo esters catalyzed by chiral diterpenoid alkaloid derivatives
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论文类型：期刊论文
发表时间：2014-09-15
发表刊物：TETRAHEDRON-ASYMMETRY
收录刊物：SCIE、Scopus
卷号：25
期号：16-17
页面范围：1215-1220
ISSN号：0957-4166
摘要：Easily accessible diterpenoid alkaloid derivatives have been used as organocatalysts in the enantioselective alpha-chlorination of beta-oxo esters. The treatment of beta-oxo esters with N-chlorophthalimide (NCP) as a chlorine source under mild reaction conditions afforded the corresponding alpha-chlorinated beta-oxo esters in excellent yields (up to 98%) and with moderate enantioselectivities (up to 68% ee) in 30 mm. (C) 2014 Elsevier Ltd. All rights reserved.