Specificity of the proteasome cleavage to the antigen protein
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发布时间：
2019-03-10
论文名称：
Specificity of the proteasome cleavage to the antigen protein
论文类型：
期刊论文
发表时间：
2009-01-01
发表刊物：
SCIENCE IN CHINA SERIES B-CHEMISTRY
收录刊物：
EI、SCIE
卷号：
52
期号：
1
页面范围：
39-47
ISSN号：
1006-9291
关键字：
proteasome; epitope; partial least squares method
摘要：
In the MHC class I molecule binding antigenic peptides processing and presentation pathway, the ubiquitin-proteasome system plays a key role in degrading the protein substrate. For the purpose of studying the specificities of proteasomal cleavage sites, partial least squares method is used to predict the proteasomal cleavage sites, and the predictive accuracy of the model is 82.8%. The specificities of the cleavage sites and the adjacent positions come from the contribution of the amino acids of the samples to the cleavage sites, showing the information of proteasome interacting with antigen protein. It demonstrates that the proteasome cleaving to target protein is selective, but not random.
学位：学士
职称：教授