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Indexed by:会议论文

Date of Publication:2010-06-26

Included Journals:EI、CPCI-S、Scopus

Volume:675-677

Page Number:369-372

Key Words:Hydrophilicity/hydrophobicity; Poly(dl-lactic-co-glycolic acid); Drug release; Degradation

Abstract:Hydrophilic ciprofloxacin hydrochloride and hydrophobic sirolimus were used as model drugs, and poly(dl-lactic-co-glycolic acid) 50/50 (PLGA 50/50) was used as the drug carrier to investigate the effects of hydrophilicity/hydrophobicity of a drug on its release properties from PLGA films. The results showed that ciprofloxacin hydrochloride induced faster release curves than sirolimus, and it also promoted the weight loss of films, while sirolimus inhibited the weight loss of films. However, both drugs inhibited the degradation of biodegradable carrier.