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Date of Publication:2020-01-01

Journal:Journal of Functional Materials

Volume:51

Issue:8

ISSN No.:1001-9731

Key Words:"variable-rate iterative electrospinning; ultrasonication reaming; small-diameter vascular graft; pore diameter gradient; compliance"

CN No.:50-1099/TH

Abstract:A small-diameter and three-layer vascular graft(3LVG)of L-polylactic acid(PLLA)and polycaprolactone( PCL)with pore diameter gradientwas prepared using a combination ofvariable-rate iterative electrospinning and ultrasonication reaming methods.The pore area,fiber diameter,and porosity were characterized.The results showed that 3LVG had distinctpore diameter gradient,and the pore diameters of its each layer,including inner layer,middle layer and outer layer,were all in the pore diameter range of the small-diameter arterial blood vessels.Axial and circular tensile tests and burst pressure test were also performed,indicating that the tensile strengths of 3LVG in axial and circular directions were similar to that of human coronary arteries.Furthermore,the compliance test revealed that the compliance of 3LVG was close to the native blood vesselunder normal human blood pressure.

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