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Date of Publication:2010-01-01

Journal:大连理工大学学报

Affiliation of Author(s):材料科学与工程学院

Issue:2

Page Number:194-197

ISSN No.:1000-8608

Abstract:Biomimetic extracellular matrix-like coatings on the surface of cardiovascular stents are effective in improving the blood compatibility. Fibrous polyurethane/(carboxymethyl chitosan / chitosan)_n composite coatings were fabricated on the substrates of 316L stainless steel by coupling an electrospinning process with an electrostatic self-assembling process. The polyurethane fibrous coatings platelet adhesion tests show that there is severe platelets adhesion on the fibers below 1 μm diameter,but there is almost no platelets adhesion on the fibers above 1 μm diameter. Furthermore,the number of platelets adhesion on the polyurethane/(carboxymethyl chitosan/chitosan)_n composite coatings decreases obviously, and the composite coatings present good blood compatibility.

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