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聚丙交酯-乙交酯共混膜与梯度膜的体外降解特性研究

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Indexed by:期刊论文

Date of Publication:2011-01-20

Journal:功能材料

Included Journals:EI、PKU、ISTIC、CSCD、Scopus

Volume:42

Issue:1

Page Number:43-46

ISSN No.:1001-9731

Key Words:聚丙交酯-乙交酯;共混膜;梯度膜;降解

Abstract:以聚丙交酯-乙交酯(PLGA)50/50与75/25为原料,采用流延法制成薄膜,其中包括PLGA50/50单成分膜、PLGA75/25单成分膜、两者的共混膜以及成分非均匀分布的梯度膜,将4种不同类型的膜浸泡在37℃、PH=7.4的磷酸盐缓冲液中进行体外降解实验.对4种膜降解过程中的分子量、质量损失、吸水率、pH值以及表面形貌等性能进行分析.结果表明,PLGA梯度膜具有最平稳的降解特性.

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