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论文类型：期刊论文

发表时间：2011-01-01

发表刊物：JOURNAL OF BIOLOGICAL RESEARCH-THESSALONIKI

收录刊物：SCIE、Scopus

卷号：15

页面范围：113-121

ISSN号：1790-045X

关键字：centrality; biological network; modularity; scale-free; small-world

摘要：The objective of this paper was to study human metabolic network core by structural and functional analysis. Firstly, we edited the human metabolic network core derived from a high-quality human metabolic network model and studied its general global structural properties (degree distribution, average path length, etc.). The human metabolic network core is a "scale-free" and "small-world" network. Then, we studied modules in human metabolic network core based on simulated annealing algorithm. The functional significance of these modules for metabolism was investigated by comparing them to KEGG metabolic pathways. Finally, we studied central metabolites in human metabolic network core by multi-centrality measures and discussed their biological implications and pharmacological insight.