张述伟

个人信息Personal Information

教授

硕士生导师

性别:男

毕业院校:大连理工大学

学位:硕士

所在单位:化工学院

电子邮箱:zswei@dlut.edu.cn

扫描关注

论文成果

当前位置: 中文主页 >> 科学研究 >> 论文成果

Prediction of PKC theta Inhibitory Activity Using the Random Forest Algorithm

点击次数:

论文类型:期刊论文

发表时间:2010-09-01

发表刊物:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

收录刊物:PubMed、SCIE、Scopus

卷号:11

期号:9

页面范围:3413-3433

ISSN号:1422-0067

关键字:protein kinase C theta; Random Forest; Partial Least Square; Support Vector Machine

摘要:This work is devoted to the prediction of a series of 208 structurally diverse PKC theta inhibitors using the Random Forest (RF) based on the Mold(2) molecular descriptors. The RF model was established and identified as a robust predictor of the experimental pIC(50) values, producing good external R-pred(2) of 0.72, a standard error of prediction (SEP) of 0.45, for an external prediction set of 51 inhibitors which were not used in the development of QSAR models. By using the RF built-in measure of the relative importance of the descriptors, an important predictor-the number of group donor atoms for H-bonds (with N and O)-has been identified to play a crucial role in PKC theta inhibitory activity. We hope that the developed RF model will be helpful in the screening and prediction of novel unknown PKC theta inhibitory activity.