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个人信息Personal Information
教授
硕士生导师
性别:男
毕业院校:大连理工大学
学位:硕士
所在单位:化工学院
电子邮箱:zswei@dlut.edu.cn
Prediction of PKC theta Inhibitory Activity Using the Random Forest Algorithm
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论文类型:期刊论文
发表时间:2010-09-01
发表刊物:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
收录刊物:PubMed、SCIE、Scopus
卷号:11
期号:9
页面范围:3413-3433
ISSN号:1422-0067
关键字:protein kinase C theta; Random Forest; Partial Least Square; Support Vector Machine
摘要:This work is devoted to the prediction of a series of 208 structurally diverse PKC theta inhibitors using the Random Forest (RF) based on the Mold(2) molecular descriptors. The RF model was established and identified as a robust predictor of the experimental pIC(50) values, producing good external R-pred(2) of 0.72, a standard error of prediction (SEP) of 0.45, for an external prediction set of 51 inhibitors which were not used in the development of QSAR models. By using the RF built-in measure of the relative importance of the descriptors, an important predictor-the number of group donor atoms for H-bonds (with N and O)-has been identified to play a crucial role in PKC theta inhibitory activity. We hope that the developed RF model will be helpful in the screening and prediction of novel unknown PKC theta inhibitory activity.