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Indexed by:期刊论文

Date of Publication:2013-01-01

Journal:JOURNAL OF ANIMAL AND VETERINARY ADVANCES

Included Journals:SCIE、Scopus

Volume:12

Issue:5

Page Number:584-588

ISSN No.:1680-5593

Key Words:Anti-fatigue activity; crude sapomns' from Panax quinquefolium; forced swimming test; mice; liver glycogen

Abstract:The present study was carried out to investigate anti-fatigue activity of Crude saponins from Panax quinquefolium (CPQS) in mice. The animals were randomly divided into four groups: control (distilled water); 50 mg kg(-1) CPQS; 100 mg kg(-1) CPQS and 200 mg kg CPQS. Distilled water or CPQS were orally administered for consecutive 28 days. The 28 days later, forced swimming test was performed and then fatigue-related biochemical parameters including blood lactic acid, serum urea nitrogen, liver glycogen and muscle glycogen were detected. The results showed that CPQS could prolong the swimming to exhaustion time of mice as well as increasing the liver and muscle glycogen contents but decrease the blood lactic acid and serum urea nitrogen levels. Therefore, the present study demonstrated that CPQS possessed anti-fatigue activity.