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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 生物工程与技术
联系方式：zhlxiu@dlut.edu.cn
电子邮箱：zhlxiu@dlut.edu.cn
Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using one strain-many compounds (OSMAC) method
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论文类型：期刊论文
发表时间：2016-12-01
发表刊物：PHYTOCHEMISTRY LETTERS
收录刊物：SCIE、Scopus
卷号：18
页面范围：157-161
ISSN号：1874-3900
关键字：Talaromyces wortmannii; Polyketides; OSMAC; Absolute configuration; Anthelmintic activity; NADH-fumarate reductase inhibitor
摘要：Three new polyketides, wortmannilactones I1-I3, were purified from Talaromyces wortmannii using the One Strain Many Compounds (OSMAC) strategy. The polyketides' structures were established using IR, 1D and 2D NMR, and HRESIMS analyses and the absolute configurations were identified by comparison of experimental and calculated ECDs. These polyketides exhibit selective inhibitory activity against NADH-fumarate reductase. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.