点击次数：

发表时间：2018-01-01

发表刊物：过程工程学报

卷号：18

期号：1

页面范围：1-10

ISSN号：1009-606X

摘要：Organic acids such as lactic acid,succinic acid,citric acid,itaconic acid,and malic acid have important application in industry.The demand for organic acids increased dramatically with the development of food,medicine and chemical synthesis.The fermentative production of organic acids has developed into an important and mature branch in the field of biological engineering.The fermentation-based routes for the industrial production of organic acids have some problems such as low product concentration,complex composition of fermentation broth and downstream processing.Because of its good hydrophilicity,similar physical and chemical properties,separating and purifying organic acids from fermentation broths is difficult.The separation of organic acids becomes the main bottleneck for organic acid production by biological processes.A number of processes for organic acids recovery from fermentation broths have been studied in the literatures,including precipitation,extraction,adsorption,ion exchange,membrane separation,electrodialysis and esterification.Through the comparison of various separation methods,it is found that a single separation method is difficult to separate organic acids effectively.The integration of different separation methods can simplify the separation process and obtain excellent separation effect.In addition,continuous or semi-continuous production of organic acid is an important direction of future fermentation industry by the novel methods of separation coupling fermentation.

备注：新增回溯数据