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论文类型：期刊论文

发表时间：2022-06-30

发表刊物：大连理工大学学报

期号：5

页面范围：771-774

ISSN号：1000-8608

摘要：Using the process of forming 1,3-propanediol by transforming glycerol using Klebsiella pneumoniae as study system, a simplified mathematical model of the nonlinear dynamic system is developed according to the cell growth kinetics of multiple-inhibitions, the metabolic overflow kinetics of substrate consumption and product formation. The identification model for this system is also established. The existence of the solution for the nonlinear dynamic system is discussed and the identifiability of the parameters is proved. Finally, the optimal control problem of batch fermentations is obtained by using the volumetric productivity of 1,3-propanediol as the objective function and the initial concentrations of glycerol and biomass and fermentation time as the control variables. The results can provide the theoretical instruction for production design of 1,3-propanediol.

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