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Indexed by:期刊论文

Date of Publication:2011-03-25

Journal:TETRAHEDRON

Included Journals:Scopus、SCIE

Volume:67

Issue:12

Page Number:2299-2304

ISSN No.:0040-4020

Key Words:Triazole; Intercalation; Anticancer; Naphthalimides

Abstract:Two novel series of 3-1,2,3-triazol-1,8-naphthalimides 5a-e, 7a-e were synthesized easily by employing 'click reaction'. Their bioactivities were evaluated. Compounds 5a-e were found to be more toxic against MCF-7 cells while 7a-e were more potent against 7721 cells, in particular 7a, the IC50 value of which against cell lines of MCF-7 and 7721 was 0.348 mu M and 0.258 mu M, respectively. Due to the phenyl group linked to 1,2,3-triazole, compound 5a not only showed higher DNA affinity but also more efficient DNA damaging ability than compound 7a. (C) 2011 Elsevier Ltd. All rights reserved.