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Indexed by:期刊论文

Date of Publication:2009-01-01

Journal:SYNTHETIC COMMUNICATIONS

Included Journals:SCIE

Volume:39

Issue:9

Page Number:1640-1654

ISSN No.:0039-7911

Key Words:Alcohols; carboxylic acid derivatives; carboxylic acids; HfCl4; KBH4; reduction

Abstract:HfCl4/KBH4 was found to be a facile, efficient, convenient, and chemoselective system for the reduction of carboxylic acids and their derivatives to the corresponding alcohols under mild conditions. HfCl4/NaBH4 was also utilized to reduce the same carboxylic acids and their derivatives, and it was found that the reducing ability of HfCl4/NaBH4 was similar to that of HfCl4/KBH4. The action of HfCl4/KBH4 on other types of substrates, such as benzyl chloride, peracid, epoxide, ketone, amide, imine, pyridine-N-oxide, and nitrile, was investigated, too. In addition, some competitive reductions of styrene oxide in the presence of carboxylic acid, carboxylic ester, nitrile, and amide were achieved.