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论文类型：期刊论文

发表时间：2009-01-01

发表刊物：SYNTHETIC COMMUNICATIONS

收录刊物：SCIE

卷号：39

期号：9

页面范围：1640-1654

ISSN号：0039-7911

关键字：Alcohols; carboxylic acid derivatives; carboxylic acids; HfCl4; KBH4; reduction

摘要：HfCl4/KBH4 was found to be a facile, efficient, convenient, and chemoselective system for the reduction of carboxylic acids and their derivatives to the corresponding alcohols under mild conditions. HfCl4/NaBH4 was also utilized to reduce the same carboxylic acids and their derivatives, and it was found that the reducing ability of HfCl4/NaBH4 was similar to that of HfCl4/KBH4. The action of HfCl4/KBH4 on other types of substrates, such as benzyl chloride, peracid, epoxide, ketone, amide, imine, pyridine-N-oxide, and nitrile, was investigated, too. In addition, some competitive reductions of styrene oxide in the presence of carboxylic acid, carboxylic ester, nitrile, and amide were achieved.