Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2012-07-01

Journal: JOURNAL OF BIOMEDICAL OPTICS

Included Journals: PubMed、SCIE

Volume: 17

Issue: 7

Page Number: 070501

ISSN: 1083-3668

Key Words: optical coherence tomography; fluorescence; atherogenesis; double-clad fiber; annexin V

Abstract: We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.070501