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Indexed by:期刊论文

Date of Publication:2012-07-01

Journal:JOURNAL OF BIOMEDICAL OPTICS

Included Journals:SCIE、PubMed

Volume:17

Issue:7

Page Number:070501

ISSN No.:1083-3668

Key Words:optical coherence tomography; fluorescence; atherogenesis; double-clad fiber; annexin V

Abstract:We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.070501