Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-07-07

Journal: TETRAHEDRON

Included Journals: Scopus、SCIE

Volume: 72

Issue: 27-28

Page Number: 3858-3862

ISSN: 0040-4020

Key Words: Trifluoromethylation; Decarboxylative coupling reaction; Arylpropiolic acids; Trifluoromethylated acetylenes; Cu(I)/Ag(I)-mediated

Abstract: A novel Cu(I)/Ag(I)-mediated decarboxylative trifluoromethylation of arylpropiolic acids with Me3SiCF3 has been developed for the construction of Csp-CF3 bond under mild conditions. This method proceeds smoothly at room temperature and shows a widely functional compatibility, providing a series of corresponding trifluoromethylated acetylenyl-containing aromatics in good yields. (C) 2016 Elsevier Ltd. All rights reserved.