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Indexed by:期刊论文

Date of Publication:2014-03-01

Journal:JOURNAL OF SURFACTANTS AND DETERGENTS

Included Journals:SCIE、EI、Scopus

Volume:17

Issue:2

Page Number:261-268

ISSN No.:1097-3958

Key Words:Synthesis; Thio galactose; Cationic lipids; Vesicle

Abstract:Two double chain cationic lipids QAS C (n) -2-S (n = 12, 14) derived from thio galactose and carbamate-linkage tertiary amine were synthesized and their structures were confirmed by MS, TOF-MS, H-1 NMR and C-13 NMR. The QAS C-12-2-S revealed superior surface activity compared with QAS C-14-2-S with lower CMC and gamma(CMC). Though Lipo C-12-2-S displayed large average particle-size with high polydispersity, positive charged Lipo C (n) -2-S can be combined with the negative charged DNA, also negatively stained TEM images confirmed the formation of vesicles. All the above prove that the Lipo C (n) -2-S is helpful for gene transfection.