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Indexed by:期刊论文

Date of Publication:2008-04-01

Journal:CHEMICAL BIOLOGY & DRUG DESIGN

Included Journals:SCIE

Volume:71

Issue:4

Page Number:336-344

ISSN No.:1747-0277

Key Words:cationic lipids; gene delivery; glycerol backbone based; transfection efficiency

Abstract:Transfection activities of two series of synthetic glycerol backbone-based cationic lipids were studied as gene delivery carriers. The variable length of hydrocarbon chains, diverse quaternary ammonium heads, different linkage, as well as alternative anion combined with them allowed to find how these factors affect cationic lipids on their gene delivery performance. The structure-function relationship of the synthetic glycerol backbone-based cationic lipids was discussed, and the transfection efficiency of some of the cationic liposomes was superior or parallel to that of two commercial transfection agents.