张淑芬

个人信息Personal Information

教授

博士生导师

硕士生导师

性别:女

毕业院校:大连理工大学

学位:博士

所在单位:化工学院

学科:应用化学. 精细化工. 有机化学

办公地点:大连市高新区凌工路2号西部校区化工楼E434房间

联系方式:0411-84986265

电子邮箱:zhangshf@dlut.edu.cn

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Synthesis of pH-responsive N-acetyl-cysteine modified starch derivatives for oral delivery

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论文类型:期刊论文

发表时间:2017-09-22

发表刊物:JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

收录刊物:SCIE、EI、PubMed、Scopus

卷号:28

期号:14

页面范围:1525-1537

ISSN号:0920-5063

关键字:Word; hydroxyethyl starch; N-acetyl-cysteine; pH-responsive; oral delivery; drug release

摘要:In this study, a novel type of pH-responsive polymer PyHES-NAC (2-hydroxy-3-(2-propynyloxy) propyl hydroxyethyl starch (PyHES)) - (N-acetyl-cysteine (NAC)) was synthesized. First, PyHES was prepared via hydrophobic modification of hydroxyl groups in hydroxyethyl starch (HES) with propynylglycidyl ether (PGE), and then pH-responsive carboxylic acid group was connected to propynyl group via thiol-yne click reaction with NAC. Aqueous PyHES-NAC solutions exhibited a good transference between hydrophobic (or self-assembly) and hydrophilic static along with the change of pH value and protective properties of drugs under acidic conditions. 10.0% DOX was released under artificial gastric fluid after 2h, whereas an immediate release (above 80%) was observed under artificial intestinal fluid. Drug loading capacity of PyHES-NAC was increased by the increase of degree of substitution (DS) of hydrophobic propynyl groups in PyHES, and 41 wt% DOX Loading capacity was the highest value in our study area.