Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2010-11-01

Journal: SYNTHESIS-STUTTGART

Included Journals: Scopus、EI、SCIE

Issue: 21

Page Number: 3602-3608

ISSN: 0039-7881

Key Words: copper catalyst; aryl bromides; aryl chlorides; cross-coupling; organic sulfides

Abstract: An efficient copper-catalyzed system for C-S cross-coupling of aromatic thiols with aryl bromides and chlorides has been developed using 1,2,3,4-tetrahydroquinoline-8-ol as a ligand. It is noteworthy that this method is proved to be especially effective for aryl bromides with electron-donating groups. By this protocol, a variety of thioethers as well as symmetrical and unsymmetrical bis-thioethers are obtained in excellent yields with an exceptional level of functional group tolerance and high chemoselectivity.