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Indexed by:期刊论文

Date of Publication:2010-11-01

Journal:SYNTHESIS-STUTTGART

Included Journals:SCIE、EI、Scopus

Issue:21

Page Number:3602-3608

ISSN No.:0039-7881

Key Words:copper catalyst; aryl bromides; aryl chlorides; cross-coupling; organic sulfides

Abstract:An efficient copper-catalyzed system for C-S cross-coupling of aromatic thiols with aryl bromides and chlorides has been developed using 1,2,3,4-tetrahydroquinoline-8-ol as a ligand. It is noteworthy that this method is proved to be especially effective for aryl bromides with electron-donating groups. By this protocol, a variety of thioethers as well as symmetrical and unsymmetrical bis-thioethers are obtained in excellent yields with an exceptional level of functional group tolerance and high chemoselectivity.