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Indexed by:期刊论文

Date of Publication:2010-03-01

Journal:CHINESE CHEMICAL LETTERS

Included Journals:SCIE、ISTIC、CSCD

Volume:21

Issue:3

Page Number:293-296

ISSN No.:1001-8417

Key Words:Triazolo-thiadiazoles; Synthesis; Bioactivity

Abstract:A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5[2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with various (un)substituted aromatic acids in the presence of phosphorous oxychloride. These compounds were investigated for their inhibitory activity to E. coli methionine aminopeptidase (EcMetAP1). Some of the tested compounds showed significant inhibitory activity. (C) 2009 Ying Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.