Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles
Release Time:2019-03-09 Hits:
Indexed by: Journal Article
Date of Publication: 2010-03-01
Journal: CHINESE CHEMICAL LETTERS
Included Journals: CSCD、ISTIC、SCIE
Volume: 21
Issue: 3
Page Number: 293-296
ISSN: 1001-8417
Key Words: Triazolo-thiadiazoles; Synthesis; Bioactivity
Abstract: A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5[2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with various (un)substituted aromatic acids in the presence of phosphorous oxychloride. These compounds were investigated for their inhibitory activity to E. coli methionine aminopeptidase (EcMetAP1). Some of the tested compounds showed significant inhibitory activity. (C) 2009 Ying Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.