Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones
Release Time:2019-03-10 Hits:
Indexed by: Journal Article
Date of Publication: 2008-10-01
Journal: CHINESE CHEMICAL LETTERS
Included Journals: Scopus、ISTIC、SCIE
Volume: 19
Issue: 10
Page Number: 1179-1182
ISSN: 1001-8417
Key Words: Bioreduction; Plant enzymes; Acenaphthenequinone; Chiral hydroxyacenaphthenone
Abstract: Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity. The (+)- and (-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach (Prunus persica (L.) Batsch., conversion 98%, 71% ee) and carrot (Daucus carota L., conversion 95%, 81% ee), respectively. (C) 2008 Jing Nan Cui. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.