大连理工大学主页平台管理系统 Cui Jingnan--Home-- Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones

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Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones

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Indexed by:期刊论文

Date of Publication:2008-10-01

Journal:CHINESE CHEMICAL LETTERS

Included Journals:SCIE、ISTIC、Scopus

Volume:19

Issue:10

Page Number:1179-1182

ISSN No.:1001-8417

Key Words:Bioreduction; Plant enzymes; Acenaphthenequinone; Chiral hydroxyacenaphthenone

Abstract:Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity. The (+)- and (-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach (Prunus persica (L.) Batsch., conversion 98%, 71% ee) and carrot (Daucus carota L., conversion 95%, 81% ee), respectively. (C) 2008 Jing Nan Cui. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.

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Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones