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蛇毒磷脂酶A2的结构与功能

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Indexed by: Journal Article

Date of Publication: 2008-06-15

Journal: 中国生物工程杂志

Included Journals: ISTIC、PKU

Issue: S1

Page Number: 251-258

ISSN: 1671-8135

Key Words: 蛇毒;磷脂酶A_2;神经毒性;肌肉毒性;抗凝血活性

Abstract: 分泌型磷脂酶A2(secretory Phospholipase A_2,sPLA_2)是蛇毒的一个重要组分,具有广泛的生物学活性,这些功能的本质是sPLA2分子及结构的多样性,从而引发各样的生理生化反应。本文简要综述了蛇毒sPLA_2的结构特征及分子生物学特性,着重论述了sPLA_2的生物活性与其结构之间的关系,并对其作用机制和研究热点进行了探讨。

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