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蛇毒磷脂酶A2的结构与功能

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Indexed by:期刊论文

Date of Publication:2008-06-15

Journal:中国生物工程杂志

Included Journals:PKU、ISTIC

Issue:S1

Page Number:251-258

ISSN No.:1671-8135

Key Words:蛇毒;磷脂酶A_2;神经毒性;肌肉毒性;抗凝血活性

Abstract:分泌型磷脂酶A2(secretory Phospholipase A_2,sPLA_2)是蛇毒的一个重要组分,具有广泛的生物学活性,这些功能的本质是sPLA2分子及结构的多样性,从而引发各样的生理生化反应。本文简要综述了蛇毒sPLA_2的结构特征及分子生物学特性,着重论述了sPLA_2的生物活性与其结构之间的关系,并对其作用机制和研究热点进行了探讨。

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