Title of Paper:Study of the theory of microbubble bursting to obtain bio-inspired alginate nanoparticles

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Date of Publication:2020-04-20

Journal:COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Included Journals:EI、SCIE

Volume:591

ISSN No.:0927-7757

Key Words:Microfluidic T-junction; Microbubble bursting; Film; disintegration; Ligament dynamics; Nanoparticle

Abstract:Through the bursting of microbubbles prepared by a T-junction microfluidic device with uniform particle size, bio-inspired alginate nanoparticles were obtained via shell disintegration process. The high-speed microscopy and digital image technology were used to observe the evolution of the microbubble raft before bubble bursting. To investigate the mechanism of nanoparticle formation, a theoretical approach combining the shell disintegration theory and the rule of the ligament breakup was developed through which the size of nanoparticles could be predicted. Such analysis showed that the bubble size and the viscosity of the alginate solution to generate bubbles were both key factors for determining the average particle size and size distribution and such results were proved experimentally. Also, the size distribution of the nanoparticles were found to be very well represented by gamma distributions, underlying the crucial role played by the ligament dynamics in building up the broad statistics of sprays.