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Indexed by:期刊论文

Date of Publication:2022-07-03

Journal:天然产物研究与开发

Volume:27

Issue:5

Page Number:890-895

ISSN No.:1001-6880

Abstract:Cyclopamine is a steroid alkaloid with Hedgehog signal pathway
   inhibitory activity and exhibits significant antitumoractivity. In this
   study, cyclopamine analogues were synthesized by reduction, oxidation
   and methylation from an available alkaloid, jervine. The structures of
   the yielded compounds were determined by MS,1 D and 2D NMR. Structures
   of compounds 4,9 and 10 have not been reported previously. The antitumor
   activities of the 10 synthesized compounds against Aspc-1 and SGC-7901
   cancer cells were evaluated by MTT method.

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