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Date of Publication:2012-01-01
Journal:大连理工大学学报
Affiliation of Author(s):实验室与设备管理处
Volume:52
Issue:2
Page Number:162-166
ISSN No.:1000-8608
Abstract:The aim of this research is to develop a rapid,accurate and no sample
preparation required method to identify 8 kinds of oral hypoglycemic
active pharmaceutical ingredient(API)(solid and liquid) by using near
infrared(NIR) spectroscopy.64 NIR spectra are utilized to establish the
calibration model and rest 32 spectra are utilized to validate the
performance of the model.On the original data,the first derivative
combined with scaling to the first range method is conducted as the
optimum pre-processing method at 12 072.3-4 000.0 cm~(-1),and 8 oral
hypoglycemic APIs can be well identified by this model.With this
approach,no error determinations are assigned to a wrong class,which
indicates that the NIR method is appropriate for fast identification of
oral hypoglycemic APIs in the inspection and acceptance before
manufacture and warehousing of drug products in the pharmaceutical
industry.
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